PMID- 16146719
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20220316
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 11
DP  - 2006 Jan 1
TI  - Stem cell factor (SCF)-kit mediated phosphatidylinositol 3 (PI3) kinase signaling 
      during mammalian oocyte growth and early follicular development.
PG  - 126-35
AB  - The bi-directional communication between mammalian oocytes and their surrounding 
      granulosa cells has been shown to be crucial for ovarian follicular development. 
      Studies on molecules derived from the oocytes, such as growth differentiation 
      factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15), have attracted great 
      interest during the past decade, and it is common knowledge nowadays that these 
      molecules participate in the bi-directional dialogue between the oocytes and 
      their surrounding granulosa cells as well as follicular development. However, 
      signaling molecules and pathways inside mammalian oocytes that control oocyte 
      growth and early development of ovarian follicles, which may be monitored by 
      factors produced by granulosa cells, have not been studied extensively. Based on 
      our own data as well as ovarian phenotypes observed in several gene modified mice 
      strains that were generated for studies of signal transduction, immunology and 
      cancer, the current review focuses on the key features of the activation of 
      oocyte phosphatidylinositol 3 kinase (PI3 kinase) pathway and its possible roles 
      during mammalian oocyte growth and follicular development. We propose that the 
      cascade from the granulosa cell-produced stem cell factor (SCF) to the oocyte 
      surface SCF receptor Kit, and to the oocyte PI3 kinase pathway, may play an 
      important role in the regulation of growth rate of mammalian oocytes, as well as 
      in the activation and development of ovarian follicles.
FAU - Liu, Kui
AU  - Liu K
AD  - Department of Medical Biochemistry and Biophysics, Umea University, S-901 87, 
      Umea, Sweden. kui.liu@medchem.umu.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060101
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (BMP15 protein, human)
RN  - 0 (Bmp15 protein, mouse)
RN  - 0 (Bone Morphogenetic Protein 15)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (GDF9 protein, human)
RN  - 0 (Gdf9 protein, mouse)
RN  - 0 (Growth Differentiation Factor 9)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Stem Cell Factor)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Protein 15
MH  - Female
MH  - Forkhead Transcription Factors/metabolism
MH  - Granulosa Cells/metabolism
MH  - Growth Differentiation Factor 9
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Models, Biological
MH  - Mutation
MH  - Oocytes/*metabolism
MH  - Ovarian Follicle/*embryology
MH  - Phenotype
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-kit/*metabolism
MH  - Signal Transduction
MH  - Stem Cell Factor/*metabolism
RF  - 69
EDAT- 2005/09/09 09:00
MHDA- 2006/06/03 09:00
CRDT- 2005/09/09 09:00
PHST- 2005/09/09 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2005/09/09 09:00 [entrez]
AID - 1785 [pii]
AID - 10.2741/1785 [doi]
PST - epublish
SO  - Front Biosci. 2006 Jan 1;11:126-35. doi: 10.2741/1785.