PMID- 16148166
OWN - NLM
STAT- MEDLINE
DCOM- 20051025
LR  - 20221207
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 12
IP  - 9
DP  - 2005 Sep
TI  - Major histocompatibility complex class II (HLA-DRB and -DQB) allele frequencies 
      in Botswana: association with human immunodeficiency virus type 1 infection.
PG  - 1020-8
AB  - Southern Africa is facing an unprecedented public health crisis due to the high 
      prevalence of human immunodeficiency virus type 1 (HIV-1). Vaccine development 
      and testing efforts, mainly based on elicitation of HIV-specific T cells, are 
      under way. To understand the role of human leukocyte antigen (HLA) class II 
      alleles in HIV pathogenesis and to facilitate HLA-based HIV-1 vaccine design, we 
      analyzed the frequencies of HLA class II alleles within the southern African 
      country of Botswana. Common HLA class II alleles were identified within the 
      Botswana population through the molecular genotyping of DRB and DQB1 loci. The 
      DRB1 allele groups DRB1*01, DRB1*02/15, DRB1*03, DRB1*11, and DRB1*13 were 
      encountered at frequencies above 20%. Within the DQB1 locus, DQB1*06 (47.7%) was 
      the most common allele group, followed by DQB1*03 (39.2%) and DQB1*04 (25.8%). We 
      found that DRB1*01 was more common in HIV-negative than in HIV-positive 
      individuals and that those who expressed DRB1*08 had lower median viral loads. We 
      demonstrate that the frequencies of certain HLA class II alleles in this Botswana 
      population differ substantially from those in North American populations, 
      including African-Americans. Common allele groups within Botswana cover large 
      percentages of other African populations and could be targeted in regional 
      vaccine designs.
FAU - Ndung'u, Thumbi
AU  - Ndung'u T
AD  - Department of Immunology and Infectious Diseases, Harvard School of Public 
      Health, 651 Huntington Avenue, FXB-402, Boston, MA 02115, USA.
FAU - Gaseitsiwe, Simani
AU  - Gaseitsiwe S
FAU - Sepako, Enoch
AU  - Sepako E
FAU - Doualla-Bell, Florence
AU  - Doualla-Bell F
FAU - Peter, Trevor
AU  - Peter T
FAU - Kim, Soyeon
AU  - Kim S
FAU - Thior, Ibou
AU  - Thior I
FAU - Novitsky, Vladimir A
AU  - Novitsky VA
FAU - Essex, Max
AU  - Essex M
LA  - eng
GR  - D43 TW000004/TW/FIC NIH HHS/United States
GR  - R01 AI043255/AI/NIAID NIH HHS/United States
GR  - R01 AI047067/AI/NIAID NIH HHS/United States
GR  - R01 HD037793/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (AIDS Vaccines)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - AIDS Vaccines
MH  - Black People/genetics
MH  - Botswana/epidemiology
MH  - Gene Frequency
MH  - HIV Infections/ethnology/*genetics/prevention & control
MH  - *HIV-1
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Prevalence
MH  - Viral Load
PMC - PMC1235800
EDAT- 2005/09/09 09:00
MHDA- 2005/10/26 09:00
PMCR- 2005/09/01
CRDT- 2005/09/09 09:00
PHST- 2005/09/09 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/09/09 09:00 [entrez]
PHST- 2005/09/01 00:00 [pmc-release]
AID - 12/9/1020 [pii]
AID - 0125-05 [pii]
AID - 10.1128/CDLI.12.9.1020-1028.2005 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 2005 Sep;12(9):1020-8. doi: 
      10.1128/CDLI.12.9.1020-1028.2005.