PMID- 16149006
OWN - NLM
STAT- MEDLINE
DCOM- 20090903
LR  - 20151119
IS  - 1671-0274 (Print)
IS  - 1671-0274 (Linking)
VI  - 8
IP  - 1
DP  - 2005 Jan
TI  - [Expression and amplification of steroid receptor coactivator-3 gene in 
      colorectal carcinoma and its clinicopathological significance].
PG  - 67-70
AB  - OBJECTIVE: To investigate the expression and amplification of steroid receptor 
      coactivator- 3(SRC- 3) gene in colorectal carcinoma (CRC) and its 
      clinicopathological significance. METHODS: Immunohistochemistry and fluorescence 
      in situ hybridization (FISH) were used to detect the expression and amplification 
      of SRC- 3 gene in CRC, and its association with patient's clinical pathological 
      features was analyzed. RESULTS: A total of 60 patients with CRC were studied. 
      SAR- 3 proteins were overexpressed in 23 cases (38% ). There was a significant 
      association between SAR- 3 overexpression and neoplasm staging (P< 0.01). SRC- 3 
      protein was overexpressed in 62% of patients with Dukes C or D stage, whereas 
      SRC- 3 protein was normally expressed in 74% of patients with Dukes A or B stage. 
      As for FISH study, 47 cases were informative. High- level amplification of SRC- 3 
      gene was detected in 6 cases(13% ) and all showed overexpression of SRC- 3 
      protein. Low- level amplification of SRC- 3 was observed in 9 cases (19% ). 
      Overexpression of SRC- 3 was detected in 6 cases. The remaining 9 of 32 
      patients(28% ) without amplification of SRC- 3 gene were observed with 
      overexpression of SRC- 3 protein. In addition, 91% patients with CRC were found 
      overexpression of SRC- 3 as well as overexpression of P53. CONCLUSION: The 
      abnormal expression of SRC- 3 gene might impact on the function of P53 and 
      development of CRC. There might exist some unknown mechanisms other than gene 
      amplification of SRC- 3 to regulate its encoded protein expression in CRC.
FAU - Zeng, Sui-de
AU  - Zeng SD
AD  - Department of Gastrointerstinal Surgery, The People's Hospital of Guangdong 
      Province, Guangzhou 510080, China.
FAU - Xie, Dan
AU  - Xie D
FAU - Lin, Feng
AU  - Lin F
FAU - Wang, Chang-xi
AU  - Wang CX
FAU - Tao, Yu
AU  - Tao Y
FAU - Zhang, Meng
AU  - Zhang M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Wei Chang Wai Ke Za Zhi
JT  - Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
JID - 101177990
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Trans-Activators)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (NCOA3 protein, human)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 3)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Colorectal Neoplasms/*genetics/*pathology
MH  - Female
MH  - Gene Expression
MH  - Histone Acetyltransferases/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nuclear Receptor Coactivator 3
MH  - Trans-Activators/*genetics
EDAT- 2005/09/09 09:00
MHDA- 2009/09/04 06:00
CRDT- 2005/09/09 09:00
PHST- 2005/09/09 09:00 [pubmed]
PHST- 2009/09/04 06:00 [medline]
PHST- 2005/09/09 09:00 [entrez]
AID - 100004492004 [pii]
PST - ppublish
SO  - Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Jan;8(1):67-70.