PMID- 16149149
OWN - NLM
STAT- MEDLINE
DCOM- 20051012
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 34
DP  - 2005 Sep 14
TI  - Effect of Gui Zhi decoction on enteric mucosal immune in mice with 
      collagen-induced arthritis.
PG  - 5373-6
AB  - AIM: To explore the effect of Gui Zhi decoction on enteric mucosal immune in type 
      II collagen-induced arthritis (CIA) in DBA mice. METHODS: Eighty DBA/1, weighing 
      18-22 g, were randomly divided into four groups with 20 in each group: control 
      group, CIA group, treatment groups at high dosage and low dosage (GZH and GZL). 
      CIA was induced by immunization with type II collagen (CII) emulsified with equal 
      complete adjuvant at 0.1 mg CII each mouse. Blood lymphocyte suspension was 
      screened for CD4 and CD8 expression using a flow cytometry, the CD4 and CD8 and 
      secretory IgA (sIgA)-positive cells in enteric lamina propria tested with 
      immunohistochemical staining. Tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-1 (IL-1)-beta, and IL-6 concentrations in serum were assayed with 
      RIA. RESULTS: Gui Zhi decoction can lower the arthritic scores and decrease the 
      occurrence of arthritis. The CD4, CD8, and sIgA-positive cells in CIA mice are 
      less than in control mice, and in Gui Zhi decoction at high dosage could restore 
      the lowered CD4- and CD8-positive cells in lamina propria, and at both high and 
      low dosages could increase the lowered sIgA-positive cells in lamina propria, 
      even still lower than in normal mice. In periphery, the CD4 cells in periphery 
      are higher in CIA mice than in control mice, and Gui Zhi decoction at high and 
      low dosages could decrease the CD4 and CD8 cells. Also, Gui Zhi decoction at high 
      dosage could decrease the IL-6 and TNF-alpha concentration in serum. CONCLUSION: 
      Gui Zhi decoction can lower the arthritic scores and decrease the incidence of 
      CIA in mice, and the mechanism is in part regulating enteric mucosal immune.
FAU - Zhou, Gui-Qin
AU  - Zhou GQ
AD  - Department of Cellular Pathology, Institute of Basic Theory, China Academy of 
      Traditional Chinese Medicine, Dongzhimen, Beijing 100700, China.
FAU - Zhao, Ning
AU  - Zhao N
FAU - Zhang, Hao
AU  - Zhang H
FAU - Jia, Hong-Wei
AU  - Jia HW
FAU - Zhang, Wan-Dong
AU  - Zhang WD
FAU - Zhao, Lin-Hua
AU  - Zhao LH
FAU - Lu, Cheng
AU  - Lu C
FAU - He, Ying-Hui
AU  - He YH
FAU - Lu, Ai-Ping
AU  - Lu AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/*drug therapy/*immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Intestinal Mucosa/*drug effects/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred DBA
PMC - PMC4622812
EDAT- 2005/09/09 09:00
MHDA- 2005/10/13 09:00
PMCR- 2005/09/14
CRDT- 2005/09/09 09:00
PHST- 2005/09/09 09:00 [pubmed]
PHST- 2005/10/13 09:00 [medline]
PHST- 2005/09/09 09:00 [entrez]
PHST- 2005/09/14 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i34.5373 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Sep 14;11(34):5373-6. doi: 10.3748/wjg.v11.i34.5373.