PMID- 16149872
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20081121
IS  - 1744-8352 (Electronic)
IS  - 1473-7159 (Linking)
VI  - 5
IP  - 5
DP  - 2005 Sep
TI  - Molecular mechanisms of the adaptive, innate and regulatory immune responses in 
      the intestinal mucosa of celiac disease patients.
PG  - 681-700
AB  - Celiac disease is a complex genetic disorder that affects the small intestine of 
      genetically predisposed individuals when they ingest gluten, a dietary protein. 
      Although several genome screens have been successful in identifying 
      susceptibility loci in celiac disease, the only genetic contributors identified 
      so far are the human leukocyte antigen (HLA)-DQ2/DQ8 molecules. One of the most 
      important aspects in the pathogenesis of celiac disease is the activation of a 
      T-helper 1 immune response, when the antigen-presenting cells that express 
      HLA-DQ2/DQ8 molecules present the toxic gluten peptides to reactive CD4(+) 
      T-cells. Recently, new insights into the activation of an innate immune response 
      have also been described. It is generally accepted that the immune response 
      triggers destruction of the mucosa in the small intestine of celiac disease 
      patients. Hence, the activation of a detrimental immune response in the intestine 
      of celiac disease patients appears to be key in the initiation and progression of 
      the disease. This review summarizes the immunologic pathways that have been 
      studied in celiac disease thus far, and will point to new potential candidate 
      genes and pathways involved in the etiopathogenesis of celiac disease, which 
      should lead to novel alternatives for diagnosis and treatment.
FAU - Diosdado, Begona
AU  - Diosdado B
AD  - University Medical Centre, Complex Genetics Section, Stratenum 2.117, Department 
      of Biomedical Genetics, PO Box 85060, 3508 AB Utrecht, The Netherlands. 
      b.diosdado@med.uu.nl
FAU - Wijmenga, Cisca
AU  - Wijmenga C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
SB  - IM
MH  - Adaptation, Physiological/immunology
MH  - Animals
MH  - Celiac Disease/*immunology/pathology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Immunity, Innate/*immunology
MH  - Intestinal Mucosa/*immunology/pathology
RF  - 136
EDAT- 2005/09/10 09:00
MHDA- 2007/01/26 09:00
CRDT- 2005/09/10 09:00
PHST- 2005/09/10 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2005/09/10 09:00 [entrez]
AID - 10.1586/14737159.5.5.681 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2005 Sep;5(5):681-700. doi: 10.1586/14737159.5.5.681.