PMID- 16151677
OWN - NLM
STAT- MEDLINE
DCOM- 20051115
LR  - 20061115
IS  - 0171-967X (Print)
IS  - 0171-967X (Linking)
VI  - 77
IP  - 3
DP  - 2005 Sep
TI  - Genetic polymorphisms of OPG, RANK, and ESR1 and bone mineral density in Korean 
      postmenopausal women.
PG  - 152-9
AB  - To evaluate the effects of genetic polymorphisms of OPG, RANK, and ESR1, which 
      regulate osteoclastogenesis, on bone mineral density (BMD), a cross-sectional 
      study was conducted in 650 Korean postmenopausal women. BMDs of the distal radius 
      and the calcaneus were measured by dual energy X-ray absorptiometry (DXA). 
      Genetic polymorphisms of OPG 163 A > G, 1181 G > C; RANK 421 C > T, 575 T > C; 
      and ESR1 1335 C > T, 2142 G > A were determined by matrix-assisted laser 
      desorption/ionization-time of flight (MALDI-ToF) mass spectrometry. The 
      differences between the BMDs of the genotypes of OPG, RANK, and ESR1 were 
      analyzed by multiple linear regression model adjusted for age and body mass 
      index. Women with the OPG 1181 CC genotype had higher BMDs at the distal radius 
      (7%) and calcaneus (10%) than those with the GG genotype; and these differences 
      were statistically significant (P = 0.001 and P = 0.007, respectively). A 
      significant association was also observed between RANK 575 T > C and calcaneus 
      BMD (P for trend = 0.017). No significant association was observed between BMDs 
      and the polymorphisms of ESR1. The association between OPG 1181 G > C and BMD was 
      profound in subjects with the RANK 575 TT or ESR1 2142 GG genotypes; women with 
      OPG 1181 CC had higher BMDs at the distal radius (11%) and calcaneus (11%) than 
      those with OPG 1181 GG only in women with RANK 575 TT genotype (P = 0.002 and P = 
      0.021, respectively). These results suggest that OPG genetic polymorphisms, 
      especially with the RANK 575 TT or ESR1 2142 GG genotypes, are related to low BMD 
      in postmenopausal Korean women.
FAU - Choi, J Y
AU  - Choi JY
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Shin, A
AU  - Shin A
FAU - Park, S K
AU  - Park SK
FAU - Chung, H W
AU  - Chung HW
FAU - Cho, S I
AU  - Cho SI
FAU - Shin, C S
AU  - Shin CS
FAU - Kim, H
AU  - Kim H
FAU - Lee, K M
AU  - Lee KM
FAU - Lee, K H
AU  - Lee KH
FAU - Kang, C
AU  - Kang C
FAU - Cho, D Y
AU  - Cho DY
FAU - Kang, D
AU  - Kang D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20050908
PL  - United States
TA  - Calcif Tissue Int
JT  - Calcified tissue international
JID - 7905481
RN  - 0 (Carrier Proteins)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Osteoprotegerin)
RN  - 0 (RANK Ligand)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNFRSF11A protein, human)
RN  - 0 (TNFRSF11B protein, human)
RN  - 0 (TNFSF11 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Density/*genetics
MH  - Carrier Proteins/*genetics/metabolism
MH  - Cross-Sectional Studies
MH  - Estrogen Receptor alpha/*genetics/radiation effects
MH  - Female
MH  - Glycoproteins/*genetics/metabolism
MH  - Humans
MH  - Korea/epidemiology
MH  - Membrane Glycoproteins/*genetics/metabolism
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/epidemiology/*genetics
MH  - Osteoprotegerin
MH  - *Polymorphism, Single Nucleotide
MH  - RANK Ligand
MH  - Receptor Activator of Nuclear Factor-kappa B
MH  - Receptors, Cytoplasmic and Nuclear/*genetics/metabolism
MH  - Receptors, Tumor Necrosis Factor/*genetics/metabolism
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
EDAT- 2005/09/10 09:00
MHDA- 2005/11/16 09:00
CRDT- 2005/09/10 09:00
PHST- 2005/04/26 00:00 [received]
PHST- 2005/05/06 00:00 [accepted]
PHST- 2005/09/10 09:00 [pubmed]
PHST- 2005/11/16 09:00 [medline]
PHST- 2005/09/10 09:00 [entrez]
AID - 10.1007/s00223-004-0264-0 [doi]
PST - ppublish
SO  - Calcif Tissue Int. 2005 Sep;77(3):152-9. doi: 10.1007/s00223-004-0264-0. Epub 
      2005 Sep 8.