PMID- 16152573
OWN - NLM
STAT- MEDLINE
DCOM- 20060127
LR  - 20221207
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 139B
IP  - 1
DP  - 2005 Nov 5
TI  - Significant association of BDNF haplotypes in European-American male smokers but 
      not in European-American female or African-American smokers.
PG  - 73-80
AB  - Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin 
      neurotransmission in the brain, both of which are involved in the reward system 
      of addiction. The BDNF gene is located in a genomic region on chromosome 11p 
      where we and others have found 'significant' linkage to nicotine dependence (ND). 
      We tested the potential role of variants within BDNF in vulnerability to ND, 
      which was assessed by Smoking Quantity (SQ), the Heaviness of Smoking Index 
      (HSI), and the Fagerstrom Test for ND (FTND). Six single nucleotide polymorphisms 
      (SNPs) in BDNF were analyzed in an extensively phenotyped cohort of 602 nuclear 
      families with smokers and non-smokers of African-American (AA) or 
      European-American (EA) ancestry. Individual SNP analysis revealed that two SNPs 
      in the pooled male and three SNPs in the EA male samples were significantly 
      associated with at least one adjusted ND measure. However, none of these 
      associations remained significant after correction for multiple testing. 
      Haplotype analysis of rs6484320-rs988748-rs2030324-rs7934165 revealed that a 
      major T-C-T-G haplotype was significantly associated, even after Bonferroni 
      correction, with the three ND measures in the pooled and EA male samples (maximum 
      Z = 3.00, P = 0.002 and maximum Z = 3.13, P = 0.0009 for SQ, respectively). No 
      significant association of a major haplotype with ND was found in the AA or EA 
      female smokers. The significant association of BDNF variants with ND implies that 
      this gene plays a role in the etiology of ND in EAs and that its involvement is 
      gender specific. BDNF may warrant further investigation in ND.
CI  - (c) 2005 Wiley-Liss, Inc.
FAU - Beuten, Joke
AU  - Beuten J
AD  - Program in Genomics and Bioinformatics on Drug Addiction, Department of 
      Psychiatry, The University of Texas Health Science Center at San Antonio, San 
      Antonio, Texas.
FAU - Ma, Jennie Z
AU  - Ma JZ
FAU - Payne, Thomas J
AU  - Payne TJ
FAU - Dupont, Randolph T
AU  - Dupont RT
FAU - Quezada, Paulina
AU  - Quezada P
FAU - Huang, Weihua
AU  - Huang W
FAU - Crews, Karen M
AU  - Crews KM
FAU - Li, Ming D
AU  - Li MD
LA  - eng
GR  - DA-12844/DA/NIDA NIH HHS/United States
GR  - GM28356/GM/NIGMS NIH HHS/United States
GR  - RR03655/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Black or African American
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - *Sex Characteristics
MH  - Smoking/*genetics/physiopathology
MH  - Tobacco Use Disorder/*genetics/physiopathology
MH  - White People
EDAT- 2005/09/10 09:00
MHDA- 2006/01/28 09:00
CRDT- 2005/09/10 09:00
PHST- 2005/09/10 09:00 [pubmed]
PHST- 2006/01/28 09:00 [medline]
PHST- 2005/09/10 09:00 [entrez]
AID - 10.1002/ajmg.b.30231 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):73-80. doi: 
      10.1002/ajmg.b.30231.