PMID- 16152661
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20131121
IS  - 0173-0835 (Print)
IS  - 0173-0835 (Linking)
VI  - 26
IP  - 20
DP  - 2005 Oct
TI  - Comparison of the use of aqueous and nonaqueous buffers in association with 
      cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and 
      related compounds.
PG  - 3904-9
AB  - A comparison of the use of aqueous and nonaqueous buffers in association with 
      beta-CD for the chiral separation of (R)- and 
      (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The 
      (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major 
      metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and 
      nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of 
      migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were 
      determined. Several electrophoretic parameters, including the concentration of 
      beta-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic 
      separation and the amount of organic solvents required for the separation, were 
      optimized.
FAU - Huang, Yu-San
AU  - Huang YS
AD  - Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
FAU - Tsai, Chung-Chen
AU  - Tsai CC
FAU - Liu, Ju-Tsung
AU  - Liu JT
FAU - Lin, Cheng-Huang
AU  - Lin CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Electrophoresis
JT  - Electrophoresis
JID - 8204476
RN  - 0 (Buffers)
RN  - 0 (Solvents)
RN  - 0 (beta-Cyclodextrins)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/isolation & purification
MH  - *Buffers
MH  - Chromatography, Micellar Electrokinetic Capillary/methods
MH  - Electrophoresis, Capillary/*methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analogs & derivatives/*isolation & 
      purification
MH  - Solvents
MH  - Stereoisomerism
MH  - beta-Cyclodextrins
EDAT- 2005/09/10 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/09/10 09:00
PHST- 2005/09/10 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/09/10 09:00 [entrez]
AID - 10.1002/elps.200410374 [doi]
PST - ppublish
SO  - Electrophoresis. 2005 Oct;26(20):3904-9. doi: 10.1002/elps.200410374.