PMID- 16154667
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20210119
IS  - 0264-410X (Print)
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 23
IP  - 50
DP  - 2005 Dec 30
TI  - A review of vaccine research and development: human acute respiratory infections.
PG  - 5708-24
AB  - Worldwide, acute respiratory infections (ARIs) constitute the leading cause of 
      acute illnesses, being responsible for nearly 4 million deaths every year, mostly 
      in young children and infants in developing countries. The main infectious agents 
      responsible for ARIs include influenza virus, respiratory syncytial virus (RSV), 
      parainfluenza virus type 3 (PIV-3), Streptococcus pneumoniae and Haemophilus 
      influenzae. While effective vaccines against influenza, H. influenzae type b 
      (Hib) and S. pneumoniae infections have been available for several years, no 
      vaccine is available at present against illnesses caused by RSV, PIV-3, 
      metapneumovirus or any of the three novel coronaviruses. In addition, the threat 
      constituted by the multiple outbreaks of avian influenza during the last few 
      years is urgently calling for the development of new influenza vaccines with 
      broader spectrum of efficacy, which could provide immunity against an avian 
      influenza virus pandemic. This article reviews the state of the art in vaccine 
      R&D against ARIs and attempts to address these basic public health questions.
FAU - Girard, Marc P
AU  - Girard MP
AD  - University Paris 7, UFR Biochemistry, 39 rue Seignemartin, FR 69008 Lyon, France. 
      marc.girard36@wanadoo.fr
FAU - Cherian, Thomas
AU  - Cherian T
FAU - Pervikov, Yuri
AU  - Pervikov Y
FAU - Kieny, Marie Paule
AU  - Kieny MP
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20050803
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Acute Disease
MH  - Humans
MH  - *Research
MH  - Respiratory Tract Infections/economics/epidemiology/*prevention & 
      control/*virology
MH  - Viral Vaccines/analysis/immunology/*isolation & 
      purification/standards/*therapeutic use
PMC - PMC7130922
EDAT- 2005/09/13 09:00
MHDA- 2006/03/03 09:00
PMCR- 2005/08/03
CRDT- 2005/09/13 09:00
PHST- 2005/05/16 00:00 [received]
PHST- 2005/07/22 00:00 [accepted]
PHST- 2005/09/13 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2005/09/13 09:00 [entrez]
PHST- 2005/08/03 00:00 [pmc-release]
AID - S0264-410X(05)00718-8 [pii]
AID - 10.1016/j.vaccine.2005.07.046 [doi]
PST - ppublish
SO  - Vaccine. 2005 Dec 30;23(50):5708-24. doi: 10.1016/j.vaccine.2005.07.046. Epub 
      2005 Aug 3.