PMID- 16154759
OWN - NLM
STAT- MEDLINE
DCOM- 20080603
LR  - 20220310
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 32
IP  - 1
DP  - 2005 Oct 7
TI  - Association of resistin with visceral fat and muscle insulin resistance.
PG  - 39-44
AB  - Maturing Sprague-Dawley (S-D) rats develop obesity and skeletal muscle insulin 
      resistance. To investigate the relationship between fat mass and insulin 
      responses, we performed surgical removal of the epididymal and retroperitoneal 
      depots of visceral adipose tissue (VF) or sham surgery (SHAM) in male rats aged 4 
      months. At sacrifice, 30 days later, the mass of visceral fat was 48% lower 
      (p<0.05) in VF- compared to SHAM, while subcutaneous fat was essentially 
      unchanged. VF- animals displayed increased insulin responses in isolated strips 
      of skeletal muscle. Insulin-stimulated glucose transport was increased 28% in 
      soleus muscle (p<0.05), with a trend toward a 31% increase in extensor digitorum 
      longus muscle (p=0.058). Glucose tolerance was not significantly affected by 
      surgical fat removal. In VF- animals, serum resistin was reduced 26% (p<0.05) and 
      serum adiponectin was reduced 30% (p<0.05), with trends for reductions in IL-4 
      (58% reduction, p=0.084) and IL-6 (56% reduction, p=0.123). TNF-alpha, leptin and 
      free fatty acids (NEFAs) were unchanged. We conclude that in maturing S-D rats, 
      increased visceral adiposity leads to an increase in systemic release in resistin 
      and possibly interleukins. Elevation of circulating cytokines may play a role in 
      the development of muscle insulin resistance.
FAU - Borst, Stephen E
AU  - Borst SE
AD  - Department of Applied Physiology and Kinesiology, University of Florida, 
      Gainesville, FL 32611-8206, USA. seborst@ufl.edu
FAU - Conover, Christine F
AU  - Conover CF
FAU - Bagby, Gregory J
AU  - Bagby GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Resistin)
SB  - IM
MH  - Aging/metabolism/physiology
MH  - Animals
MH  - Fatty Acids, Nonesterified/blood
MH  - Glucose Tolerance Test
MH  - Insulin Resistance/*physiology
MH  - Intra-Abdominal Fat/*metabolism
MH  - Male
MH  - Muscle, Skeletal/*metabolism/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Resistin/blood/*metabolism
EDAT- 2005/09/13 09:00
MHDA- 2008/06/05 09:00
CRDT- 2005/09/13 09:00
PHST- 2005/05/11 00:00 [received]
PHST- 2005/07/26 00:00 [accepted]
PHST- 2005/09/13 09:00 [pubmed]
PHST- 2008/06/05 09:00 [medline]
PHST- 2005/09/13 09:00 [entrez]
AID - S1043-4666(05)00244-9 [pii]
AID - 10.1016/j.cyto.2005.07.008 [doi]
PST - ppublish
SO  - Cytokine. 2005 Oct 7;32(1):39-44. doi: 10.1016/j.cyto.2005.07.008.