PMID- 16155260
OWN - NLM
STAT- MEDLINE
DCOM- 20051101
LR  - 20230318
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 82
IP  - 3
DP  - 2005 Sep
TI  - Elevated atopy in healthy obese women.
PG  - 504-9
AB  - BACKGROUND: Allergic disorders, including asthma, have increased dramatically in 
      the United States in the past 20 y. Epidemiologic studies have found body mass 
      index (body weight in kg/height squared in m) to be a positive independent 
      correlate of atopy in women but not in men. OBJECTIVE: We investigated the 
      prevalence of atopy among healthy obese and nonobese women and its relation to 
      fat mass (FM), insulin resistance, and plasma concentrations of 17beta-estradiol, 
      interleukin 4 (IL-4), and leptin. DESIGN: A cross-sectional study of 21 obese (> 
      or = 30% body fat) and 22 nonobese (< 30% body fat) women (18-41 y of age) was 
      performed. The following measurements were taken: FM by plethysmography, total 
      and specific immunoglobulin E (IgE) by automated immunosorbent analysis, and 
      blood glucose, insulin, C-peptide, 17beta-estradiol, sex hormone-binding 
      globulin, and IL-4. Insulin sensitivity was determined on the basis of the 
      fasting insulin resistance index and with an oral-glucose-tolerance test. 
      RESULTS: The frequency of specific IgE in the obese group was almost 3 times that 
      in the nonobese group (P = 0.008). The total IgE concentration was not 
      significantly different between groups. Plasma concentrations of 
      17beta-estradiol, the ratio of 17beta-estradiol to sex hormone-binding globulin, 
      the fasting insulin resistance index, and C-peptide and leptin concentrations 
      were higher in the obese than in the nonobese group (P < 0.05) after adjustment 
      for oral contraceptive use. All factors correlated positively with FM. Logistic 
      regression showed FM to be the only positive predictor of specific IgE (P = 
      0.01). CONCLUSION: The findings confirm a direct relation between obesity and a T 
      helper 2 cell immune response in women.
FAU - Vieira, Victoria J
AU  - Vieira VJ
AD  - Department of Animal and Nutritional Sciences, University of New Hampshire, 
      Durham, NH 03824, USA.
FAU - Ronan, Anne M
AU  - Ronan AM
FAU - Windt, Mark R
AU  - Windt MR
FAU - Tagliaferro, Anthony R
AU  - Tagliaferro AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Leptin)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Estradiol/*blood
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hypersensitivity/blood/*epidemiology/immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Insulin Resistance/*physiology
MH  - Interleukin-4/*blood
MH  - Leptin/*blood
MH  - Logistic Models
MH  - Obesity/blood/immunology/*physiopathology
MH  - Prevalence
MH  - Sex Factors
MH  - Sex Hormone-Binding Globulin/analysis
EDAT- 2005/09/13 09:00
MHDA- 2005/11/03 09:00
CRDT- 2005/09/13 09:00
PHST- 2005/09/13 09:00 [pubmed]
PHST- 2005/11/03 09:00 [medline]
PHST- 2005/09/13 09:00 [entrez]
AID - S0002-9165(23)29594-5 [pii]
AID - 10.1093/ajcn.82.3.504 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2005 Sep;82(3):504-9. doi: 10.1093/ajcn.82.3.504.