PMID- 16155571
OWN - NLM
STAT- MEDLINE
DCOM- 20051102
LR  - 20220330
IS  - 1529-2908 (Print)
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Linking)
VI  - 6
IP  - 10
DP  - 2005 Oct
TI  - Activation of bone marrow-resident memory T cells by circulating, antigen-bearing 
      dendritic cells.
PG  - 1029-37
AB  - Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to 
      lymph nodes. We report here that differentiated DCs can also travel from the 
      periphery into the blood. Circulating DCs migrated to the spleen, liver and lung 
      but not lymph nodes. They also homed to the bone marrow, where they were retained 
      better than in most other tissues. Homing of DCs to the bone marrow depended on 
      constitutively expressed vascular cell adhesion molecule 1 and endothelial 
      selectins in bone marrow microvessels. Two-photon intravital microscopy in bone 
      marrow cavities showed that DCs formed stable antigen-dependent contacts with 
      bone marrow-resident central memory T cells. Moreover, using this previously 
      unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory 
      T cell-mediated recall responses in the bone marrow.
FAU - Cavanagh, Lois L
AU  - Cavanagh LL
AD  - The CBR Institute for Biomedical Research and Department of Pathology, Harvard 
      Medical School, Boston, Massachusetts 02115, USA.
FAU - Bonasio, Roberto
AU  - Bonasio R
FAU - Mazo, Irina B
AU  - Mazo IB
FAU - Halin, Cornelia
AU  - Halin C
FAU - Cheng, Guiying
AU  - Cheng G
FAU - van der Velden, Adrianus W M
AU  - van der Velden AW
FAU - Cariappa, Annaiah
AU  - Cariappa A
FAU - Chase, Catherine
AU  - Chase C
FAU - Russell, Paul
AU  - Russell P
FAU - Starnbach, Michael N
AU  - Starnbach MN
FAU - Koni, Pandelakis A
AU  - Koni PA
FAU - Pillai, Shiv
AU  - Pillai S
FAU - Weninger, Wolfgang
AU  - Weninger W
FAU - von Andrian, Ulrich H
AU  - von Andrian UH
LA  - eng
GR  - AI061663/AI/NIAID NIH HHS/United States
GR  - HL56949/HL/NHLBI NIH HHS/United States
GR  - HL54936/HL/NHLBI NIH HHS/United States
GR  - HL62524/HL/NHLBI NIH HHS/United States
GR  - R01 HL054936/HL/NHLBI NIH HHS/United States
GR  - P01 HL056949/HL/NHLBI NIH HHS/United States
GR  - R01 AI061663/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050911
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Selectins)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Blood Vessels/metabolism
MH  - Bone Marrow/blood supply/*immunology
MH  - Cell Movement
MH  - Dendritic Cells/*immunology
MH  - Endothelium, Vascular/metabolism
MH  - Immunologic Memory
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Congenic
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Selectins/metabolism
MH  - T-Lymphocytes/*immunology
MH  - Vascular Cell Adhesion Molecule-1/metabolism
PMC - PMC1780273
MID - NIHMS6717
EDAT- 2005/09/13 09:00
MHDA- 2005/11/03 09:00
PMCR- 2007/12/18
CRDT- 2005/09/13 09:00
PHST- 2005/06/13 00:00 [received]
PHST- 2005/08/08 00:00 [accepted]
PHST- 2005/09/13 09:00 [pubmed]
PHST- 2005/11/03 09:00 [medline]
PHST- 2005/09/13 09:00 [entrez]
PHST- 2007/12/18 00:00 [pmc-release]
AID - ni1249 [pii]
AID - 10.1038/ni1249 [doi]
PST - ppublish
SO  - Nat Immunol. 2005 Oct;6(10):1029-37. doi: 10.1038/ni1249. Epub 2005 Sep 11.