PMID- 16156507
OWN - NLM
STAT- MEDLINE
DCOM- 20051005
LR  - 20211203
IS  - 0916-9636 (Print)
IS  - 0916-9636 (Linking)
VI  - 28
IP  - 5
DP  - 2005 May
TI  - Nifedipine enhances the cardioprotective effect of an angiotensin-II receptor 
      blocker in an experimental animal model of heart failure.
PG  - 431-8
AB  - This study was designed to examine the hypothesis that a calcium channel blocker 
      nifedipine (CCB) could enhance the cardioprotective effect of an angiotensin-ll 
      receptor blocker candesartan (ARB) in the treatment for heart failure. 
      Isoproterenol (ISP) was injected into male rats at 300 mg/kg to produce 
      progressive heart failure. Three months later, the rats were divided into 4 
      groups and treated for 4 weeks with 1) vehicle (n = 20), 2) ARB at 0.2 mg/kg/day 
      (n = 6), 3) CCB at 10 mg/kg/day (n = 6), or 4) both drugs (n = 8). Rats injected 
      with saline served as controls (n = 13). ISP caused severe myocardial 
      degeneration and decreased the capillary density (D(cap)) of the left ventricular 
      (LV) myocardium (mean +/- SD: 2,197 +/- 627 vs. 2,847 +/- 298 N/mm2 for normal 
      controls), while increasing plasma thiobarbituric acid-reactive substances 
      (TBARS; 3.6 +/- 1.1 vs. 1.9 +/- 0.5 nmol/ml). Although ARB therapy preserved 
      cardiac morphology, it had little effect on D(cap) or oxidative stress. On the 
      other hand, CCB decreased plasma TBARS and 4-hydroxy-2-nonenal protein expression 
      in LV myocardium. Furthermore, the combination of CCB and ARB increased D(cap) 
      and preserved the ultrastructure of LV myocardium, so this combination may be a 
      useful option for the treatment of heart failure.
FAU - Okuda, Nobuaki
AU  - Okuda N
AD  - Third Department of Medicine, Osaka Medical College, Takatsuki, Japan.
FAU - Hayashi, Tetsuya
AU  - Hayashi T
FAU - Mori, Tatsuhiko
AU  - Mori T
FAU - Inamoto, Sakiko
AU  - Inamoto S
FAU - Okabe, Makoto
AU  - Okabe M
FAU - Mieno, Shigetoshi
AU  - Mieno S
FAU - Horimoto, Hitoshi
AU  - Horimoto H
FAU - Kitaura, Yasushi
AU  - Kitaura Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Benzimidazoles)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Tetrazoles)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - I9ZF7L6G2L (Nifedipine)
RN  - S8Q36MD2XX (candesartan)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/*pharmacology
MH  - Animals
MH  - Benzimidazoles/*pharmacology
MH  - Biphenyl Compounds
MH  - Body Weight
MH  - Calcium Channel Blockers/*pharmacology
MH  - Capillaries
MH  - Cardiotonic Agents/pharmacology
MH  - Coronary Circulation
MH  - Disease Models, Animal
MH  - Drug Synergism
MH  - Heart Failure/*drug therapy/metabolism/pathology
MH  - Hypertension/complications/drug therapy
MH  - Male
MH  - Microscopy, Electron
MH  - Myocardium/pathology/ultrastructure
MH  - Nifedipine/*pharmacology
MH  - Organ Size
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tetrazoles/*pharmacology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Ventricular Pressure
EDAT- 2005/09/15 09:00
MHDA- 2005/10/06 09:00
CRDT- 2005/09/15 09:00
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2005/10/06 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
AID - 10.1291/hypres.28.431 [doi]
PST - ppublish
SO  - Hypertens Res. 2005 May;28(5):431-8. doi: 10.1291/hypres.28.431.