PMID- 16157197
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20131121
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 162
IP  - 1
DP  - 2005 Oct 1
TI  - 9q34 rearrangements in BCR/ABL fusion-negative acute lymphoblastic leukemia.
PG  - 30-7
AB  - The t(9;22)(q11.2;q34) translocation is found in a subset of acute lymphoblastic 
      leukemia (ALL). The presence of this translocation involving the fusion of 
      BCR/ABL genes represents a poor prognostic group. Because of the importance in 
      detecting t(9;22) in ALL patients and because occasionally a cytogenetically 
      cryptic BCR/ABL fusion is detected with fluorescence in situ hybridization 
      (FISH), our laboratory routinely performs BCR/ABL FISH tests on all newly 
      diagnosed ALL patients. In the past year, 25 consecutive, newly diagnosed, 
      untreated ALL cases were analyzed. We report the cytogenetics and FISH findings 
      of three cases containing a rearranged 9q34 region with an intact BCR (22q11.2) 
      region and an absence of the BCR/ABL fusion. A split ABL signal representing a 
      translocation of the 9q34 region with chromosome segments other than 22q11.2 
      (BCR) was observed in 3 cases. Two of these patients were 3 years old; one was 21 
      at the time of diagnosis. A split ABL FISH signal without the involvement of BCR 
      does not represent a t(9;22) translocation, and prognostic implications of this 
      apparent subgroup of ALL cases have not been determined. Cytogenetic, pathologic, 
      and clinical aspects of these three cases are presented.
FAU - Dave, Bhavana J
AU  - Dave BJ
AD  - Human Genetics Laboratory, Munroe Meyer Institute for Genetics and 
      Rehabilitation, University of Nebraska Medical Center, 985440 Nebraska Medical 
      Center, Omaha, NE 68198-5440, USA. bdave@unmc.edu
FAU - Wiggins, Michele
AU  - Wiggins M
FAU - Higgins, Christine M
AU  - Higgins CM
FAU - Pickering, Diane L
AU  - Pickering DL
FAU - Perry, Deborah
AU  - Perry D
FAU - Aoun, Patricia
AU  - Aoun P
FAU - Abromowich, Minnie
AU  - Abromowich M
FAU - DeVetten, Marcel
AU  - DeVetten M
FAU - Sanger, Warren G
AU  - Sanger WG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Adult
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Fusion Proteins, bcr-abl
MH  - *Gene Rearrangement
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Translocation, Genetic
EDAT- 2005/09/15 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/09/15 09:00
PHST- 2004/06/21 00:00 [received]
PHST- 2005/03/07 00:00 [revised]
PHST- 2005/03/09 00:00 [accepted]
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
AID - S0165-4608(05)00154-8 [pii]
AID - 10.1016/j.cancergencyto.2005.03.005 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Oct 1;162(1):30-7. doi: 
      10.1016/j.cancergencyto.2005.03.005.