PMID- 16157207
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20151119
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 162
IP  - 1
DP  - 2005 Oct 1
TI  - Deletion 6q is not a characteristic marker of nodal lymphoplasmacytic lymphoma.
PG  - 85-8
AB  - Lymphoplasmacytic lymphoma (LPL) is a small B-cell neoplasm with plasmacytic 
      differentiation that does not fulfill the criteria for any other type of B-cell 
      leukemia or lymphoma. In many cases, LPL is associated with Waldenstrom 
      macroglobulinemia (WM), although WM may also be associated with other types of 
      lymphoma. Recent studies have demonstrated that del(6q) is the most common 
      structural abnormality in patients with bone marrow-based LPL. It is unknown 
      whether del(6q) might also be associated with nodal LPL. We, therefore, examined 
      10 well-characterized LPL involving lymph nodes or other extramedullary tissues 
      for del(6q) using paraffin section interphase fluorescence in situ hybridization 
      (FISH). Dual-color FISH was performed using a chromosome 6 centromere probe 
      (CEP6) and a probe for 6q21 (RP11-91C23). The latter probe has previously been 
      reported as deleted in up to 63% of cases of bone marrow-based LPL. In contrast, 
      no nuclei containing a del(6q) pattern were identified in any case of 
      extramedullary LPL examined in this study, and 89-98.5% of nuclei contained a 
      normal signal pattern. These results indicate that del(6q) is at least uncommon 
      in nodal LPL, and cannot be employed as a diagnostic marker to identify this type 
      of lymphoma. Furthermore, these findings suggest that nodal LPL and bone 
      marrow-based cases of LPL may be associated with different cytogenetic findings.
FAU - Cook, James R
AU  - Cook JR
AD  - Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH, 
      USA.
FAU - Aguilera, Nadine Ives
AU  - Aguilera NI
FAU - Reshmi, Shalini
AU  - Reshmi S
FAU - Huang, Xin
AU  - Huang X
FAU - Yu, Zhisheng
AU  - Yu Z
FAU - Gollin, Susanne M
AU  - Gollin SM
FAU - Abbondanzo, Susan L
AU  - Abbondanzo SL
FAU - Swerdlow, Steven H
AU  - Swerdlow SH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 6
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Lymphoma, B-Cell/genetics
EDAT- 2005/09/15 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/09/15 09:00
PHST- 2005/03/23 00:00 [received]
PHST- 2005/04/15 00:00 [accepted]
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
AID - S0165-4608(05)00220-7 [pii]
AID - 10.1016/j.cancergencyto.2005.04.013 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Oct 1;162(1):85-8. doi: 
      10.1016/j.cancergencyto.2005.04.013.