PMID- 16157452
OWN - NLM
STAT- MEDLINE
DCOM- 20051215
LR  - 20081121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 390
IP  - 2
DP  - 2005 Dec 23
TI  - Macrosialin increases during normal brain aging are attenuated by caloric 
      restriction.
PG  - 76-80
AB  - During normal aging, microglia develop an activated phenotype characterized by 
      morphologic changes and induction of CD11b, MHC II, and other inflammatory 
      markers. We show that macrosialin (CD68), a macrophage-specific protein, is 
      increased by aging in selected brain regions of male C57BL/6NNia mice. In corpus 
      callosum and striatum, macrosialin mRNA and protein increased >or=50% (24 months 
      versus 4 months); hippocampus and cerebellum were unchanged. Caloric restriction 
      (CR) attenuated these age-related increases. Since CR attenuates age-related 
      increases in oxidative damage and inflammation, we examined whether oxidized 
      lipoproteins and inflammatory processes regulate macrosialin using murine BV-2 
      microglial cells as a model. Oxidized low-density lipoproteins (oxLDL) induced 
      macrosialin protein by 50%. Moreover, macrosialin was induced in response to 
      lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) which activates 
      inflammatory pathways in BV-2 cells. Thus, the previously documented increase in 
      oxidized lipoproteins, inflammation, and microglial activation during normal 
      aging may contribute to the age-related increase in macrosialin expression.
FAU - Wong, Angela M
AU  - Wong AM
AD  - Andrus Gerontology Center and Department of Biological Sciences, University of 
      Southern California, Los Angeles, CA 90089-0191, USA. angelawo@usc.edu
FAU - Patel, Nilay V
AU  - Patel NV
FAU - Patel, Nimesh K
AU  - Patel NK
FAU - Wei, Min
AU  - Wei M
FAU - Morgan, Todd E
AU  - Morgan TE
FAU - de Beer, Maria C
AU  - de Beer MC
FAU - de Villiers, Willem J S
AU  - de Villiers WJ
FAU - Finch, Caleb E
AU  - Finch CE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD68 protein, mouse)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Antigens, CD/*metabolism
MH  - Antigens, Differentiation, Myelomonocytic/*metabolism
MH  - Brain/anatomy & histology/*metabolism
MH  - *Caloric Restriction
MH  - Cell Line
MH  - Humans
MH  - Inflammation/metabolism
MH  - Interferon-gamma/immunology
MH  - Lipopolysaccharides/immunology
MH  - Lipoproteins, LDL/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
EDAT- 2005/09/15 09:00
MHDA- 2005/12/16 09:00
CRDT- 2005/09/15 09:00
PHST- 2005/05/17 00:00 [received]
PHST- 2005/07/13 00:00 [revised]
PHST- 2005/07/30 00:00 [accepted]
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2005/12/16 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
AID - S0304-3940(05)00881-5 [pii]
AID - 10.1016/j.neulet.2005.07.058 [doi]
PST - ppublish
SO  - Neurosci Lett. 2005 Dec 23;390(2):76-80. doi: 10.1016/j.neulet.2005.07.058.