PMID- 1615796
OWN - NLM
STAT- MEDLINE
DCOM- 19920730
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 124
IP  - 1
DP  - 1992 Jul
TI  - Determinants of the renal response to ACE inhibition in patients with congestive 
      heart failure.
PG  - 131-6
AB  - The objective of the present study was to determine whether pretreatment 
      neurohormonal and renal hemodynamic parameters predict the change in renal 
      function with the administration of quinapril, a new angiotensin-converting 
      enzyme (ACE) inhibitor. Twenty patients with New York Heart Association (NYHA) 
      class III and IV heart failure were evaluated. Following pretreatment 
      determination of renal function and plasma neurohormones, patients were treated 
      daily with 10 mg of quinapril. Measurements of glomerular filtration rate (GFR) 
      and renal plasma flow (RPF) were repeated after 7 weeks to assess changes in 
      function (delta GFR and delta RPF). Mean GFR increased from 49 +/- 6 to 56 +/- 7 
      ml/min/1.73 m2 (p = 0.10), but decreased in five patients. Mean RPF increased 
      from 235 +/- 23 to 252 +/- 23 ml/min/1.73 m2 (p = 0.08), but decreased in five 
      patients. There was no relation between delta GFR and baseline determinations of 
      GFR, RPF, plasma renin activity, plasma angiotensin II, or serum Na. Only a high 
      filtration fraction (GFR/RPF) predicted a decreased GFR (r = 0.61, p less than 
      0.005). In contrast, no baseline renal hemodynamic parameter correlated with 
      delta RPF. We conclude that poor renal function does not increase the risk of 
      renal deterioration with quinapril. However, dependence of renal function upon 
      the renin-angiotensin system may be predicted by a high filtration fraction.
FAU - Gottlieb, S S
AU  - Gottlieb SS
AD  - Department of Medicine, University of Maryland School of Medicine, Baltimore 
      21201.
FAU - Robinson, S
AU  - Robinson S
FAU - Weir, M R
AU  - Weir MR
FAU - Fisher, M L
AU  - Fisher ML
FAU - Krichten, C M
AU  - Krichten CM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Isoquinolines)
RN  - 0 (Tetrahydroisoquinolines)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.23.15 (Renin)
RN  - RJ84Y44811 (Quinapril)
SB  - IM
MH  - Angiotensin II/blood
MH  - Angiotensin-Converting Enzyme Inhibitors/*pharmacology
MH  - Female
MH  - Heart Failure/drug therapy/*physiopathology
MH  - Humans
MH  - Isoquinolines/*pharmacology
MH  - Kidney/*drug effects
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Quinapril
MH  - Renal Circulation/drug effects
MH  - Renin/blood
MH  - Renin-Angiotensin System/drug effects
MH  - Risk Factors
MH  - *Tetrahydroisoquinolines
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 0002-8703(92)90930-T [pii]
AID - 10.1016/0002-8703(92)90930-t [doi]
PST - ppublish
SO  - Am Heart J. 1992 Jul;124(1):131-6. doi: 10.1016/0002-8703(92)90930-t.