PMID- 16159986
OWN - NLM
STAT- MEDLINE
DCOM- 20060508
LR  - 20191210
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 92
IP  - 4
DP  - 2006 Apr
TI  - Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left 
      atrial size and reversal to sinus rhythm.
PG  - 490-4
AB  - OBJECTIVE: To evaluate the impact of long term cardiac resynchronisation therapy 
      (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal 
      to sinus rhythm (SR) in patients with heart failure with atrial fibrillation 
      (AF). PATIENTS: 74 consecutive patients (age 68 (8) years; 67 men) with advanced 
      heart failure and AF (20 persistent and 54 permanent) were implanted with a CRT 
      device. MAIN OUTCOME MEASURES: Patients were evaluated clinically (New York Heart 
      Association (NYHA) class, quality of life, six minute walk test) and 
      echocardiographically (LV ejection fraction, LV diameters, and left atrial 
      diameters) before and after six months of CRT. Additionally, restoration of SR 
      was evaluated after six months of CRT. RESULTS: NYHA class, quality of life 
      score, six minute walk test, and LV ejection fraction had improved significantly 
      after six months of CRT. In addition, left atrial and LV end diastolic and end 
      systolic diameters had decreased from 59 (9) to 55 (9) mm, from 72 (10) to 67 
      (10) mm, and from 61 (11) to 56 (11) mm, respectively (all p < 0.01). During 
      implantation 18 of 20 (90%) patients with persistent AF were cardioverted to SR. 
      At follow up 13 of 18 (72%) patients had returned to AF and none had 
      spontaneously reverted to SR; thus, only 5 of 74 (7%) were in SR. CONCLUSION: Six 
      months of CRT resulted in significant clinical benefit with significant left 
      atrial and LV reverse remodelling. Despite these beneficial effects, 93% of 
      patients had not reverted to SR.
FAU - Kies, P
AU  - Kies P
AD  - Department of Cardiology, Leiden University Medical Centre, The Netherlands.
FAU - Leclercq, C
AU  - Leclercq C
FAU - Bleeker, G B
AU  - Bleeker GB
FAU - Crocq, C
AU  - Crocq C
FAU - Molhoek, S G
AU  - Molhoek SG
FAU - Poulain, C
AU  - Poulain C
FAU - van Erven, L
AU  - van Erven L
FAU - Bootsma, M
AU  - Bootsma M
FAU - Zeppenfeld, K
AU  - Zeppenfeld K
FAU - van der Wall, E E
AU  - van der Wall EE
FAU - Daubert, J-C
AU  - Daubert JC
FAU - Schalij, M J
AU  - Schalij MJ
FAU - Bax, J J
AU  - Bax JJ
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20050913
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/diagnostic imaging/etiology/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Exercise Test
MH  - Female
MH  - Heart Atria/diagnostic imaging/pathology
MH  - Heart Failure/complications/diagnostic imaging/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Quality of Life
MH  - Treatment Outcome
MH  - Ultrasonography
PMC - PMC1860874
COIS- Competing interests: none declared
EDAT- 2005/09/15 09:00
MHDA- 2006/05/09 09:00
PMCR- 2009/04/01
CRDT- 2005/09/15 09:00
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2006/05/09 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
PHST- 2009/04/01 00:00 [pmc-release]
AID - hrt.2005.064816 [pii]
AID - ht64816 [pii]
AID - 10.1136/hrt.2005.064816 [doi]
PST - ppublish
SO  - Heart. 2006 Apr;92(4):490-4. doi: 10.1136/hrt.2005.064816. Epub 2005 Sep 13.