PMID- 16159987
OWN - NLM
STAT- MEDLINE
DCOM- 20060609
LR  - 20181113
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 92
IP  - 5
DP  - 2006 May
TI  - Comparison of endothelial vasodilator function, inflammatory markers, and 
      N-terminal pro-brain natriuretic peptide in patients with or without chronotropic 
      incompetence to exercise test.
PG  - 609-14
AB  - OBJECTIVE: To investigate the role of endothelial function, inflammatory markers, 
      and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with 
      impaired chronotropic response during exercise test. METHODS: 86 subjects were 
      enrolled. Treadmill exercise test was conducted according to the modified Bruce 
      protocols. Brachial ultrasound was used to measure endothelium dependent flow 
      mediated vasodilatation (FMD). Chronotropic incompetence was defined as either 
      failure to achieve 85% of the age predicted maximum heart rate or a low 
      chronotropic index (< 0.8). RESULTS: Of the 86 patients, 20 (23%) exhibited 
      chronotropic incompetence. The patients were divided into three groups according 
      to chronotropic index: group 1, < 0.8 (n = 20); group 2, 0.8-1.0 (n = 26); and 
      group 3, > 1.0 (n = 40). Patients with impaired chronotropic response had 
      significantly lower FMD than those with higher chronotropic response (mean (SD) 
      2.8 (1.9)% v 5.0 (2.8)% v 5.3 (2.5)%, p = 0.002, for groups 1, 2, and 3, 
      respectively). Serum concentrations of high-sensitivity C reactive protein 
      (hsCRP), monocyte chemoattractant protein-1 (MCP-1), and NT-proBNP were 
      significantly higher in group 1 than in groups 2 and 3 (hsCRP: 19 (12) v 9 (6) v 
      9 (6) mg/l, p < 0.05; MCP-1: 140 (51) v 133 (60) v 108 (46) pg/ml, p = 0.046; 
      NT-proBNP: 4760 (1980) v 3710 (850) v 3910 (1060) mg/l, p = 0.019, respectively). 
      In addition, chronotropic index was significantly related to FMD (r = 0.380, p = 
      0.001) and inversely related to hsCRP (r = -0.267, p = 0.013). By multivariate 
      analysis, impaired chronotropic response was significantly related to endothelial 
      dysfunction (p = 0.012). CONCLUSION: Patients with impaired chronotropic response 
      to graded exercise had endothelial dysfunction, enhanced systemic inflammation, 
      and higher NT-proBNP concentrations. These findings may partly explain the 
      mechanism of chronotropic incompetence as a predictor of cardiovascular risk and 
      increased mortality.
FAU - Huang, P-H
AU  - Huang PH
AD  - Division of Cardiology, Department of Internal Medicine, Taipei Veterans General 
      Hospital, Taipei, Taiwan.
FAU - Leu, H-B
AU  - Leu HB
FAU - Chen, J-W
AU  - Chen JW
FAU - Wu, T-C
AU  - Wu TC
FAU - Lu, T-M
AU  - Lu TM
FAU - Ding, Y-A
AU  - Ding YA
FAU - Lin, S-J
AU  - Lin SJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050913
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Chemokine CCL2)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
CIN - Heart. 2006 May;92(5):577-8. PMID: 16387820
MH  - Adult
MH  - Aged
MH  - Brachial Artery/physiology
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Endothelium, Vascular/*physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*metabolism
MH  - Nitroglycerin/pharmacology
MH  - Peptide Fragments/*metabolism
MH  - Vasodilation/drug effects
PMC - PMC1860951
EDAT- 2005/09/15 09:00
MHDA- 2006/06/10 09:00
PMCR- 2009/05/01
CRDT- 2005/09/15 09:00
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2006/06/10 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
PHST- 2009/05/01 00:00 [pmc-release]
AID - hrt.2005.064147 [pii]
AID - ht64147 [pii]
AID - 10.1136/hrt.2005.064147 [doi]
PST - ppublish
SO  - Heart. 2006 May;92(5):609-14. doi: 10.1136/hrt.2005.064147. Epub 2005 Sep 13.