PMID- 16160187
OWN - NLM
STAT- MEDLINE
DCOM- 20051021
LR  - 20181113
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 79
IP  - 19
DP  - 2005 Oct
TI  - Conversion of mouse mammary tumor virus to a lymphomagenic virus.
PG  - 12592-6
AB  - Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that 
      causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that 
      conversion of a mammotropic MMTV to a T-cell-tropic virus requires two 
      alterations in the long terminal repeat: (i) acquisition of a T-cell-specific 
      enhancer and (ii) loss of transcriptional repression through deletion of negative 
      regulatory elements (NREs) or by suppression of NRE activity after appropriate 
      positioning of the enhancer.
FAU - Bhadra, Sanchita
AU  - Bhadra S
AD  - Section of Molecular Genetics and Microbiology, The University of Texas at 
      Austin, Austin, TX 78712-0162, USA.
FAU - Lozano, Mary M
AU  - Lozano MM
FAU - Dudley, Jaquelin P
AU  - Dudley JP
LA  - eng
GR  - P01 CA077760/CA/NCI NIH HHS/United States
GR  - P01 CA77760/CA/NCI NIH HHS/United States
GR  - R01 CA34780/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Enhancer Elements, Genetic
MH  - *Genes, Regulator
MH  - Humans
MH  - Jurkat Cells
MH  - Lymphoma, T-Cell/virology
MH  - Mammary Neoplasms, Experimental/virology
MH  - Mammary Tumor Virus, Mouse/*genetics/*pathogenicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Proviruses/genetics/pathogenicity
MH  - Retroviridae Infections/virology
MH  - T-Lymphocytes/virology
MH  - *Terminal Repeat Sequences
MH  - Transcription, Genetic
MH  - Transfection
MH  - Tumor Virus Infections/virology
PMC - PMC1211542
EDAT- 2005/09/15 09:00
MHDA- 2005/10/22 09:00
PMCR- 2005/10/01
CRDT- 2005/09/15 09:00
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2005/10/22 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
PHST- 2005/10/01 00:00 [pmc-release]
AID - 79/19/12592 [pii]
AID - 0885-05 [pii]
AID - 10.1128/JVI.79.19.12592-12596.2005 [doi]
PST - ppublish
SO  - J Virol. 2005 Oct;79(19):12592-6. doi: 10.1128/JVI.79.19.12592-12596.2005.