PMID- 16160878
OWN - NLM
STAT- MEDLINE
DCOM- 20061212
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 183
IP  - 1
DP  - 2005 Nov
TI  - Behavioral effects of urotensin-II centrally administered in mice.
PG  - 103-17
AB  - Urotensin-II (U-II) receptors are widely distributed in the central nervous 
      system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension 
      and bradycardia and stimulates prolactin and thyrotropin secretion. However, the 
      behavioral effects of centrally administered U-II have received little attention. 
      In the present study, we tested the effects of i.c.v. injections of U-II on 
      behavioral, metabolic, and endocrine responses in mice. Administration of graded 
      doses of U-II (1-10,000 ng/mouse) provoked: (1) a dose-dependent reduction in the 
      number of head dips in the hole-board test; (2) a dose-dependent reduction in the 
      number of entries in the white chamber in the black-and-white compartment test, 
      and in the number of entries in the central platform and open arms in the 
      plus-maze test; and (3) a dose-dependent increase in the duration of immobility 
      in the forced-swimming test and tail suspension test. Intracerebroventricular 
      injection of U-II also caused an increase in: food intake at doses of 100 and 
      1,000 ng/mouse, water intake at doses of 100-10,000 ng/mouse, and horizontal 
      locomotion activity at a dose of 10,000 ng/mouse. Whatever was the dose, the 
      central administration of U-II had no effect on body temperature, nociception, 
      apomorphine-induced penile erection and climbing behavior, and stress-induced 
      plasma corticosterone level. Taken together, the present study demonstrates that 
      the central injection of U-II at doses of 1-10,000 ng/mouse induces anxiogenic- 
      and depressant-like effects in mouse. These data suggest that U-II may be 
      involved in some aspects of psychiatric disorders.
FAU - Do-Rego, Jean-Claude
AU  - Do-Rego JC
AD  - Institut Federatif de Recherches Multidisciplinaires sur les Peptides (IFRMP 23), 
      Laboratoire de Neuropsychopharmacologie Experimentale, CNRS FRE 2735, UFR de 
      Medecine et Pharmacie, 76183 Rouen Cedex, France. jean.costentin@univ-rouen.fr
FAU - Chatenet, David
AU  - Chatenet D
FAU - Orta, Marie-Helene
AU  - Orta MH
FAU - Naudin, Bertrand
AU  - Naudin B
FAU - Le Cudennec, Camille
AU  - Le Cudennec C
FAU - Leprince, Jerome
AU  - Leprince J
FAU - Scalbert, Elizabeth
AU  - Scalbert E
FAU - Vaudry, Hubert
AU  - Vaudry H
FAU - Costentin, Jean
AU  - Costentin J
LA  - eng
PT  - Journal Article
DEP - 20051022
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Urotensins)
RN  - 9047-55-6 (urotensin II)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Temperature/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drinking/drug effects
MH  - Eating/drug effects
MH  - Exploratory Behavior/drug effects
MH  - Injections, Intraventricular
MH  - Locomotion/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Molecular Sequence Data
MH  - Time Factors
MH  - Urotensins/administration & dosage/*pharmacology
EDAT- 2005/09/15 09:00
MHDA- 2006/12/13 09:00
CRDT- 2005/09/15 09:00
PHST- 2005/06/27 00:00 [received]
PHST- 2005/07/21 00:00 [accepted]
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2006/12/13 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
AID - 10.1007/s00213-005-0140-2 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2005 Nov;183(1):103-17. doi: 
      10.1007/s00213-005-0140-2. Epub 2005 Oct 22.