PMID- 16161053
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20160303
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 118
IP  - 5
DP  - 2006 Mar 1
TI  - Premenopausal levels of circulating insulin-like growth factor I and the risk of 
      postmenopausal breast cancer.
PG  - 1279-84
AB  - Increased levels of insulin-like growth factor I (IGF-I) may directly stimulate 
      breast cell proliferation and promote growth and survival of transformed cells. 
      Higher levels of IGF-I have been associated with increased risk of premenopausal 
      breast cancer but not postmenopausal breast cancer. We investigated whether 
      circulating levels of IGF-I prior to menopause are associated with breast cancer 
      diagnosed after menopause in a population-based nested case-control study. Female 
      cohort participants were enrolled in 1974 (n = 15,192) and 1989 (n = 18,724) and 
      blood was drawn. Cases were women diagnosed with primary breast cancer at ages > 
      or =50, of whom 152 were premenopausal at blood draw. One control was matched to 
      each case on cohort participation, age, ethnic group, menopausal status and date 
      of blood draw. Levels of IGF-I and IGF binding protein 3 (IGFBP-3) were measured 
      using enzyme-linked immunoabsorbent assays. The association between IGF-I and 
      breast cancer was determined using conditional logistic regression, adjusting for 
      IGFBP-3. IGF-I levels decreased with age (p = 0.0001). Prior to 
      age-stratification, IGF-I levels neither measured before nor after menopause were 
      associated with postmenopausal breast cancer. After age-stratification, 
      associations were suggested in the youngest premenopausal age group (upper vs. 
      lowest third: odds ratio (OR) = 5.31, 95% confidence intervals (CI) = 0.85-33.13; 
      p trend = 0.06) and oldest postmenopausal age group (upper vs. lowest third: OR = 
      3.41, 95% CI = 0.66-17.71; p trend = 0.13). The association between circulating 
      levels of IGF-I and postmenopausal breast cancer risk may be modified by age. 
      Increased levels of circulating IGF-I may be of particular interest in the 
      younger premenopausal women and older postmenopausal women. Age-stratification 
      should be undertaken in larger investigations of IGF-I levels as predictors of 
      postmenopausal breast cancer.
CI  - (c) 2005 Wiley-Liss, Inc.
FAU - Rollison, Dana E
AU  - Rollison DE
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 
      North Wolfe Street, Room E-6142, Baltimore, MD 21205, USA.
FAU - Newschaffer, Craig J
AU  - Newschaffer CJ
FAU - Tao, Yuzhen
AU  - Tao Y
FAU - Pollak, Michael
AU  - Pollak M
FAU - Helzlsouer, Kathy J
AU  - Helzlsouer KJ
LA  - eng
GR  - 2T32 CA 09314-19/CA/NCI NIH HHS/United States
GR  - CA 88843-02/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*blood/epidemiology
MH  - Disease Susceptibility/*blood
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Middle Aged
MH  - Postmenopause/*physiology
MH  - Premenopause/*blood
MH  - Risk Factors
EDAT- 2005/09/15 09:00
MHDA- 2006/03/03 09:00
CRDT- 2005/09/15 09:00
PHST- 2005/09/15 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2005/09/15 09:00 [entrez]
AID - 10.1002/ijc.21471 [doi]
PST - ppublish
SO  - Int J Cancer. 2006 Mar 1;118(5):1279-84. doi: 10.1002/ijc.21471.