PMID- 16162955
OWN - NLM
STAT- MEDLINE
DCOM- 20051122
LR  - 20181113
IS  - 0017-5749 (Print)
IS  - 1458-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 54
IP  - 10
DP  - 2005 Oct
TI  - Extraoesophageal manifestations of gastro-oesophageal reflux.
PG  - 1492-9
AB  - A variety of pulmonary and ear, nose, and throat (ENT) symptoms and disorders are 
      considered to be extraoesophageal manifestations of gastro-oesophageal reflux 
      disease (GORD). These extraoesophageal manifestations include asthma, chronic 
      cough, laryngeal disorders, and various ENT symptoms. Recent studies have 
      established that GORD underlies or contributes to chronic sinusitis, chronic 
      otitis media, paroxysmal laryngospasm, excessive throat phlegm, and postnasal 
      drip. Traditionally, management of extraoesophageal GORD manifestations relies on 
      prolonged empiric therapy with high doses of proton pump inhibitors (PPI), 
      followed by pH monitoring under PPI in refractory cases. Recent studies found no 
      benefit of empiric long term high dose PPI therapy. The diagnostic yield of 
      endoscopy in extraoesophageal GORD manifestations seems higher than previously 
      appreciated while pH monitoring under PPI therapy has a low yield. Based on these 
      new findings, a new management algorithm can be proposed that uses short term 
      empiric PPI therapy and GORD investigations off PPI. Well designed controlled 
      studies evaluating the proposed management algorithms and treatment approaches in 
      this area are urgently needed.
FAU - Poelmans, J
AU  - Poelmans J
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals 
      Leuven, Belgium.
FAU - Tack, J
AU  - Tack J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Algorithms
MH  - Asthma/etiology/therapy
MH  - Chronic Disease
MH  - Cough/etiology/therapy
MH  - Gastroesophageal Reflux/*complications
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Laryngeal Diseases/etiology/therapy
MH  - Lung Diseases/etiology/therapy
MH  - Otitis Media/etiology/therapy
MH  - Otorhinolaryngologic Diseases/etiology/therapy
MH  - Proton Pump Inhibitors
PMC - PMC1774710
EDAT- 2005/09/16 09:00
MHDA- 2005/12/13 09:00
PMCR- 2008/10/01
CRDT- 2005/09/16 09:00
PHST- 2005/09/16 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/16 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - 54/10/1492 [pii]
AID - 0541492 [pii]
AID - 10.1136/gut.2004.053025 [doi]
PST - ppublish
SO  - Gut. 2005 Oct;54(10):1492-9. doi: 10.1136/gut.2004.053025.