PMID- 16163950
OWN - NLM
STAT- MEDLINE
DCOM- 20051222
LR  - 20190902
IS  - 0425-1644 (Print)
IS  - 0425-1644 (Linking)
VI  - 37
IP  - 5
DP  - 2005 Sep
TI  - Functional consequences of cartilage degeneration in the equine 
      metacarpophalangeal joint: quantitative assessment of cartilage stiffness.
PG  - 462-7
AB  - REASONS FOR PERFORMING STUDY: No quantitative data currently exist on the 
      relationship of the occurrence of cartilage degeneration and changes in 
      site-specific biomechanical properties in the metacarpophalangeal (MCP) joint in 
      the horse. OBJECTIVES: To gain insight into the biomechanical consequences of 
      cartilage deterioration at 2 differently loaded sites on the proximal articular 
      surface of the proximal phalanx (P1). HYPOTHESIS: Static and dynamic stiffness of 
      articular cartilage decreases significantly in degenerated cartilage. METHODS: 
      Cartilage degeneration index (CDI) values were measured at the lateral dorsal 
      margin (Site 1), lateral central fovea (Site 2) and entire joint surface of P1 
      (CDIP1) in 30 horses. Group 1 contained joints without (CDIP1 values <25 %, n = 
      22) and Group 2 joints with (CDIP1 values >25 %, n = 8) signs of cartilage 
      degeneration. Cartilage thickness at Sites 1 and 2 was measured using ultrasonic 
      and needle-probe techniques. Osteochondral plugs were drilled out from Sites 1 
      and 2 and subsequently tested biomechanically in indentation geometry. Young's 
      modulus at equilibrium and dynamic modulus were determined. RESULTS: Cartilage 
      thickness values were not significantly different between the 2 groups and sites. 
      Young's modulus at Site 1 was significantly higher in Group 1 than in Group 2; at 
      Site 2, the difference was not significant. Dynamic modulus values were 
      significantly higher in Group 1 than in Group 2 at both sites. CONCLUSIONS: 
      Degenerative cartilage changes are clearly related to loss of stiffness of the 
      tissue. Absolute changes in cartilage integrity in terms of CDI are greatest at 
      the joint margin, but concomitant changes are also present at the centre, with a 
      comparable decrease of the biomechanical moduli at the 2 sites. Therefore, 
      significant cartilage degradation at the joint margin not only reflects local 
      deterioration of biomechanical properties, but is also indicative of the 
      functional quality in the centre. POTENTIAL RELEVANCE: These findings may be 
      important for improving prognostication and developing preventative measures.
FAU - Brommer, H
AU  - Brommer H
AD  - Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht 
      University, Yalelaan 12, 3584 CM, Utrecht, The Netherlands.
FAU - Laasanen, M S
AU  - Laasanen MS
FAU - Brama, P A J
AU  - Brama PA
FAU - van Weeren, P R
AU  - van Weeren PR
FAU - Helminen, H J
AU  - Helminen HJ
FAU - Jurvelin, J S
AU  - Jurvelin JS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Equine Vet J
JT  - Equine veterinary journal
JID - 0173320
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Cadaver
MH  - Cartilage Diseases/diagnosis/pathology/physiopathology/*veterinary
MH  - Cartilage, Articular/*pathology/physiology/physiopathology
MH  - Horse Diseases/diagnosis/*pathology/physiopathology
MH  - Horses
MH  - Metacarpophalangeal Joint/*pathology/physiology/physiopathology
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2005/09/17 09:00
MHDA- 2005/12/24 09:00
CRDT- 2005/09/17 09:00
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2005/12/24 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
AID - 10.2746/042516405774480012 [doi]
PST - ppublish
SO  - Equine Vet J. 2005 Sep;37(5):462-7. doi: 10.2746/042516405774480012.