PMID- 16164241
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20180222
IS  - 0029-0831 (Print)
IS  - 0029-0831 (Linking)
VI  - 37
IP  - 5
DP  - 2005 Sep
TI  - [Continuous midazolam infusion for refractory nonconvulsive status epilepticus in 
      children].
PG  - 369-73
AB  - We examined efficacy of continuous midazolam (MDL) infusion in seven episodes of 
      refractory nonconvulsive status epilepticus (NCSE) in five children. Diagnosis 
      included Lennox-Gastaut syndrome (two cases), and symptomatic generalized 
      epilepsy, ring chromosome 20 syndrome, and epilepsy with continuous spike-waves 
      during slow-wave sleep (one case each). One patient with Lennox-Gastaut syndrome 
      and another with ring chromosome 20 syndrome had two episodes of NCSE. MDL was 
      given as an initial bolus of 0.15 to 0.3 mg/kg, followed by continuous 
      intravenous infusion at 0.1 to 0.2 mg/kg/hr. The infusion rate was increased 
      slowly by 0.1 mg/kg/hr every 0.5 to 1.0 hr, up to 0.4 mg/kg/hr or until NCSE was 
      controlled. The electroencephalogram, vital signs, blood pressure, and oxygen 
      saturation were monitored during therapy. Electrical status epilepticus was 
      abolished within a few hours in five of the seven episodes, and two patients 
      could maintain wakefulness, oral intake, and bowel and bladder control throughout 
      the continuous infusion. In one patient in whom NCSE recurred, it then remained 
      uncontrolled even at a maximum dose. Serious complications such as respiratory 
      depression or hypotension were not observed. Continuous intravenous infusion of 
      MDL was effective and safe for NCSE in children, and can be used as firstline 
      therapy for this condition.
FAU - Nobutoki, Tatsuro
AU  - Nobutoki T
AD  - Department of Child Neurology, National Center Hospital for Mental, Nervous and 
      Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo. 
      nobutokit@mie-m.hosp.go.jp
FAU - Sugai, Kenji
AU  - Sugai K
FAU - Fukumizu, Michio
AU  - Fukumizu M
FAU - Hanaoka, Shigeru
AU  - Hanaoka S
FAU - Sasaki, Masayuki
AU  - Sasaki M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - No To Hattatsu
JT  - No to hattatsu = Brain and development
JID - 0215224
RN  - 0 (Anesthetics, Intravenous)
RN  - R60L0SM5BC (Midazolam)
SB  - IM
MH  - Adolescent
MH  - Anesthetics, Intravenous/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Drug Administration Schedule
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Midazolam/*administration & dosage
MH  - Status Epilepticus/*drug therapy/physiopathology
EDAT- 2005/09/17 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/09/17 09:00
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
PST - ppublish
SO  - No To Hattatsu. 2005 Sep;37(5):369-73.