PMID- 16164437
OWN - NLM
STAT- MEDLINE
DCOM- 20060117
LR  - 20050916
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 35
IP  - 9
DP  - 2005 Sep
TI  - Dendritic cells in asthma: a function beyond sensitization.
PG  - 1125-34
AB  - Allergic asthma is one of the most common chronic diseases in western society, 
      characterized by variable airway obstruction, mucus hypersecretion and 
      infiltration of the airway wall with T-helper type 2 (Th2) cells, eosinophils and 
      mast cells. If we are to devise new causal therapies for this disease, it is 
      important to elucidate how Th2 cells are activated and respond to intrinsically 
      harmless allergens. Dendritic cells (DCs) are the most important 
      antigen-presenting cells in the lung and are mainly recognized for their 
      exceptional potential to generate a primary immune response and sensitization to 
      aeroallergens. Much less attention has been paid to the role of DCs in 
      established inflammation. Based on functional studies in a murine model for 
      asthma, in this review article, we propose that DCs are essential for generating 
      allergen-specific effector Th2 responses in ongoing inflammation in sensitized 
      mice. A better understanding of the role of DCs in the maintenance of the 
      inflammatory response to allergens in asthma should lead to new therapeutic 
      approaches intervening at the top of the inflammatory cascade.
FAU - van Rijt, L S
AU  - van Rijt LS
AD  - Department of Pulmonary Medicine, Erasmus University Medical Center, Dr 
      Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. L.vanrijt@erasmusmc.nl
FAU - Lambrecht, B N
AU  - Lambrecht BN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Antigen Presentation
MH  - Asthma/*immunology/pathology
MH  - Chronic Disease
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lung/*immunology/pathology
MH  - Mice
MH  - Models, Animal
MH  - Respiratory Hypersensitivity
MH  - Th2 Cells/*immunology
RF  - 88
EDAT- 2005/09/17 09:00
MHDA- 2006/01/18 09:00
CRDT- 2005/09/17 09:00
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
AID - CEA2321 [pii]
AID - 10.1111/j.1365-2222.2005.02321.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2005 Sep;35(9):1125-34. doi: 10.1111/j.1365-2222.2005.02321.x.