PMID- 16166739
OWN - NLM
STAT- MEDLINE
DCOM- 20060110
LR  - 20171116
IS  - 1044-1549 (Print)
IS  - 1044-1549 (Linking)
VI  - 33
IP  - 6
DP  - 2005 Dec
TI  - Involvement of discoidin domain receptor 1 in the deterioration of pulmonary 
      sarcoidosis.
PG  - 565-73
AB  - The prognosis of sarcoidosis with pulmonary infiltrates differs in each case, and 
      several cytokines are reported to contribute to its deterioration. However, the 
      detailed mechanism has not been fully elucidated. Discoidin domain receptor 1 
      (DDR1) is a receptor tyrosine kinase activated by collagen and associated with 
      cytokine production from inflammatory cells. We previously reported the 
      functional expression of DDR1 on CD14-positive bronchoalveolar lavage fluid 
      (BALF) cells in vivo. In this study, we hypothesized that DDR1 might be 
      associated with the deterioration of pulmonary sarcoidosis (PS), and investigated 
      33 patients with sarcoidosis with pulmonary infiltrates, prospectively. We found 
      that patients with deteriorated PS showed significantly higher DDR1 expression in 
      CD14-positive BALF cells predominant with DDR1b isoforms. Activation of DDR1 
      induced monocyte chemoattractant protein-1 (MCP-1) and matrix metalloproteinase-9 
      (MMP-9) production in a p38 mitogen-activated protein kinase-dependent manner 
      from CD14-positive BALF cells of patients with deteriorated sarcoidosis. DDR1 
      activation also induced NF-kappaB nuclear translocation in CD14-positive BALF 
      cells of patients with deteriorated PS. The inhibitor of NF-kappaB inhibited the 
      production of MCP-1 and MMP-9. We propose that DDR1 is associated with the 
      deterioration of pulmonary sarcoidosis.
FAU - Matsuyama, Wataru
AU  - Matsuyama W
AD  - Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima 
      University Hospital, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan. 
      vega@xa2.so-net.ne.jp
FAU - Mitsuyama, Hideo
AU  - Mitsuyama H
FAU - Watanabe, Masaki
AU  - Watanabe M
FAU - Shirahama, Yuko
AU  - Shirahama Y
FAU - Higashimoto, Ikkou
AU  - Higashimoto I
FAU - Osame, Mitsuhiro
AU  - Osame M
FAU - Arimura, Kimiyoshi
AU  - Arimura K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20050915
PL  - United States
TA  - Am J Respir Cell Mol Biol
JT  - American journal of respiratory cell and molecular biology
JID - 8917225
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (NF-kappa B)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Mitogen)
RN  - EC 2.7.10.1 (Discoidin Domain Receptors)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
RIN - Shapiro SD. Am J Respir Cell Mol Biol. 2008 Sep;39(3):380. PMID: 18695263
MH  - Antibodies, Monoclonal/pharmacology
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Case-Control Studies
MH  - Cell Nucleus/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Discoidin Domain Receptors
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lipopolysaccharide Receptors/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Middle Aged
MH  - NF-kappa B/metabolism
MH  - Phosphorylation
MH  - Prospective Studies
MH  - Protein Isoforms
MH  - Protein Transport
MH  - Receptor Protein-Tyrosine Kinases/immunology/*metabolism
MH  - Receptors, Mitogen/agonists/immunology/*metabolism
MH  - Sarcoidosis, Pulmonary/*metabolism/pathology
MH  - Up-Regulation
MH  - p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
EDAT- 2005/09/17 09:00
MHDA- 2006/01/13 09:00
CRDT- 2005/09/17 09:00
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
AID - 2005-0236OC [pii]
AID - 10.1165/rcmb.2005-0236OC [doi]
PST - ppublish
SO  - Am J Respir Cell Mol Biol. 2005 Dec;33(6):565-73. doi: 10.1165/rcmb.2005-0236OC. 
      Epub 2005 Sep 15.