PMID- 16166801
OWN - NLM
STAT- MEDLINE
DCOM- 20060501
LR  - 20161124
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 102
IP  - 1
DP  - 2006
TI  - Serum level of macrophage colony-stimulating factor and atherosclerosis in 
      hemodialysis patients.
PG  - c14-20
AB  - BACKGROUND/AIMS: Atherosclerosis and its related complications are the leading 
      causes of death in the hemodialysis (HD) population. Aortic calcification index 
      (ACI), intima-media thickness (IMT) in common carotid arteries, and 
      electrocardiogram (ECG) are atherosclerotic parameters that are available in 
      usual clinical outpatient settings. Macrophage colony-stimulating factor (MCSF) 
      and monocyte chemoattractant protein-1 (MCP-1) play important roles in 
      atherosclerosis. METHODS: We performed a cross-sectional study of 133 outpatients 
      on maintenance HD in a single HD outpatient center. We measured serum levels of 
      MCSF and MCP-1, determined the ACI using computed tomography scan and the IMT 
      using high-sensitivity ultrasound B-mode imaging, and performed ECGs. RESULTS: 
      Stepwise multivariate regression analysis revealed that the MCSF level correlated 
      with age-adjusted mean and maximum IMT (F = 10.811, p = 0.001, and F = 6.784, p = 
      0.010, respectively) as well as with the diastolic blood pressure. Age and MCSF 
      level (F = 4.866, p = 0.029) were independently related to an increased ACI. 
      High-sensitivity C-reactive protein (hsCRP) was not related to IMT and ACI. The 
      hsCRP level (chi2 = 5.002, p = 0.025) correlated with ECG changes followed by 
      MCSF (chi2 = 3.940, p = 0.047). MCP-1 was not related to the above 
      atherosclerotic parameters. CONCLUSION: A head-to-head comparison between MCSF 
      and hsCRP revealed that MCSF was more closely associated with IMT and ACI in HD 
      patients.
CI  - 2006 S. Karger AG, Basel.
FAU - Haraguchi, Kazutaka
AU  - Haraguchi K
AD  - 3rd Department of Internal Medicine, University of Yamanashi, Kofu, Japan. 
      kazutaka@swallow.res.yamanashi-med.ac.jp
FAU - Kubo, Masashi
AU  - Kubo M
FAU - Saito, Takehiro
AU  - Saito T
FAU - Furuya, Fumihiko
AU  - Furuya F
FAU - Inoue, Hironobu
AU  - Inoue H
FAU - Takahashi, Mitsuhiko
AU  - Takahashi M
FAU - Shimura, Hiroki
AU  - Shimura H
FAU - Tago, Kiichiro
AU  - Tago K
FAU - Kobayashi, Tetsuro
AU  - Kobayashi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050913
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atherosclerosis/*blood/epidemiology
MH  - C-Reactive Protein/analysis
MH  - Carotid Arteries/diagnostic imaging
MH  - Chemokine CCL2/*blood
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*blood/epidemiology/therapy
MH  - Logistic Models
MH  - Macrophage Colony-Stimulating Factor/*blood
MH  - Macrophages/physiology
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis
MH  - Tunica Intima/pathology
MH  - Tunica Media/pathology
MH  - Ultrasonography
EDAT- 2005/09/17 09:00
MHDA- 2006/05/02 09:00
CRDT- 2005/09/17 09:00
PHST- 2004/11/24 00:00 [received]
PHST- 2005/05/30 00:00 [accepted]
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2006/05/02 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
AID - 88294 [pii]
AID - 10.1159/000088294 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2006;102(1):c14-20. doi: 10.1159/000088294. Epub 2005 Sep 13.