PMID- 16167290
OWN - NLM
STAT- MEDLINE
DCOM- 20051104
LR  - 20171206
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 15
IP  - 5
DP  - 2005 Sep-Oct
TI  - Topical nonsteroidal anti-inflammatory drugs in uncomplicated cataract surgery: 
      effect of sodium naproxen.
PG  - 598-606
AB  - PURPOSE: To investigate whether topical nonsteroidal antiinflammatory drugs 
      (NSAIDs) are useful, in the absence of concomitant corticosteroid therapy, in 
      limiting postoperative inflammation after uncomplicated cataract surgery. 
      METHODS: A total of 328 patients were enrolled in a prospective, randomized, 
      double-masked, parallel-group, active-controlled study. Anterior chamber 
      inflammation (ACI) was evaluated as the primary efficacy parameter. Only patients 
      with moderate inflammation (ACI score of < or =4) the day after surgery were 
      randomized and treated with NSAIDs. A novel topical formulation containing 0.2% 
      sodium naproxen was compared with 0.1% diclofenac. Both were administered three 
      times a day for 14 consecutive days. Ocular inflammation was measured after 7 and 
      14 days by using slit-lamp biomicroscopy. Safety parameters were also evaluated 
      at the same time. RESULTS: Both treatments were equally effective in controlling 
      postsurgical inflammation. No statistically significant differences between 
      treatment groups were observed for the safety variables. No serious adverse 
      events (AEs) occurred during the course of the study. The most frequent AE 
      reported with naproxen was eye redness. CONCLUSIONS: NSAIDs can effectively be 
      used without concurrent administration of corticosteroids to control 
      postoperative inflammation after uncomplicated cataract surgery. In addition, 
      naproxen ophthalmic solution may be considered a suitable alternative to the 
      currently available NSAIDs.
FAU - Russo, P
AU  - Russo P
AD  - Medical Department SIFI SpA, Catania, Italy. piero_russo@sifi.it
FAU - Papa, V
AU  - Papa V
FAU - Russo, S
AU  - Russo S
FAU - Di Bella, A
AU  - Di Bella A
FAU - Pabst, G
AU  - Pabst G
FAU - Milazzo, G
AU  - Milazzo G
FAU - Balestrazzi, A
AU  - Balestrazzi A
FAU - Caporossi, A
AU  - Caporossi A
CN  - Naproxen Study Group
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 57Y76R9ATQ (Naproxen)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/adverse effects
MH  - Diclofenac/*administration & dosage/adverse effects
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Inflammation/prevention & control
MH  - Lens Implantation, Intraocular
MH  - Male
MH  - Middle Aged
MH  - Naproxen/*administration & dosage/adverse effects
MH  - *Phacoemulsification
MH  - Postoperative Complications/*prevention & control
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Uveitis, Anterior/*prevention & control
EDAT- 2005/09/17 09:00
MHDA- 2005/11/05 09:00
CRDT- 2005/09/17 09:00
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2005/11/05 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
PST - ppublish
SO  - Eur J Ophthalmol. 2005 Sep-Oct;15(5):598-606.