PMID- 16167294
OWN - NLM
STAT- MEDLINE
DCOM- 20051104
LR  - 20191210
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 15
IP  - 5
DP  - 2005 Sep-Oct
TI  - A new, heavier-than-water silicone oil: a solution of perfluorohexyloctane in 
      polydimethylsiloxane.
PG  - 627-37
AB  - PURPOSE: To pre p a re and explore new solutions of semifluorinated alkane in 
      silicone oil, which have a specific gravity slightly higher than silicone oil and 
      vitreous fluid (referred to in the following as heavier-than-water silicone oils 
      (HWSs), and to investigate, in vitro, whether HWSs can be used to plug retina 
      holes, while allowing dehydration of the subretinal space. METHODS: HWS solutions 
      were pre p a red with silicone oil 5000 and perfluorohexyloctane (F6H8). The 
      stability was investigated under different conditions. The viscosity was 
      determined by means of a capillary viscometer. The surface and interface tension 
      were measured using the ring method. RESULTS: HWSs are insoluble in an aqueous 
      medium. Densiron(R)68 (HWS 1.06) is a transparent homogeneous liquid which is 
      slightly heavier (1.06 g/cm3) than water and has a refractive index close to that 
      of vitreous liquid. Densiron68 (HWS 1.06) has a low viscosity (1480 mPas) and 
      interface tension (40.82 mN/m), making it an effective tamponade in the surgical 
      treatment of an inferior detached retina. In addition, the interfaces between 
      Densiron68 and other perfluorocarbon liquids are clearly visible. However, the 
      interface layer between Densiron68 and water is not clear. Finally, all HWSs are 
      stable over the long term at ambient temperatures, as well as physically and 
      thermally resistant. CONCLUSIONS. Due to its physiochemical properties, 
      Densiron68 could meet the requirements for a heavier-than-water tamponade.
FAU - Kim, Y K
AU  - Kim YK
AD  - Fluoron GmbH, Neu-Ulm, Germany.
FAU - Gunther, B
AU  - Gunther B
FAU - Meinert, H
AU  - Meinert H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Drug Combinations)
RN  - 0 (Fluorocarbons)
RN  - 0 (Ophthalmic Solutions)
RN  - 0 (Silicone Oils)
RN  - 0 (Silicones)
RN  - 63148-62-9 (baysilon)
RN  - 7VYX4ELWQM (perfluorohexyl-octan)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Dimethylpolysiloxanes/*chemistry/toxicity
MH  - Drainage
MH  - Drug Combinations
MH  - Drug Stability
MH  - Fluorocarbons/*chemistry/toxicity
MH  - Humans
MH  - L Cells/drug effects
MH  - Mice
MH  - Ophthalmic Solutions/chemistry/toxicity
MH  - Pigment Epithelium of Eye/drug effects
MH  - Refractometry
MH  - Silicone Oils/*chemistry/toxicity
MH  - Silicones/*chemistry/toxicity
MH  - Specific Gravity
MH  - Surface Tension
MH  - Viscosity
EDAT- 2005/09/17 09:00
MHDA- 2005/11/05 09:00
CRDT- 2005/09/17 09:00
PHST- 2005/09/17 09:00 [pubmed]
PHST- 2005/11/05 09:00 [medline]
PHST- 2005/09/17 09:00 [entrez]
PST - ppublish
SO  - Eur J Ophthalmol. 2005 Sep-Oct;15(5):627-37.