PMID- 16167418
OWN - NLM
STAT- MEDLINE
DCOM- 20051026
LR  - 20161124
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 4
IP  - 5
DP  - 2005 Sep-Oct
TI  - A large 12-month extension study of an 8-week trial to evaluate the safety and 
      efficacy of triple combination (TC) cream in melasma patients previously treated 
      with TC cream or one of its dyads.
PG  - 592-7
AB  - This was a 12-month extension of a randomized, investigator-blinded, multicenter, 
      8-week trial with triple combination (TC) cream in facial melasma. A total of 585 
      patients were enrolled in the study and 569 patients received study medication. 
      Three hundred eighty-nine patients completed 6 months of treatment and 327 
      patients completed 12 months of treatment. TC cream demonstrated a favorable 
      safety profile: only 14 patients (2.5%) discontinued the study due to 
      treatment-related adverse events (AEs). The 2 cases of skin atrophy were mild and 
      did not lead to withdrawal. From the 23 cases of mild telangiectasia, only 2 
      resulted in discontinuation. All others were transient. Results confirmed those 
      of a previous smaller study, with both physicians and patients reporting 
      clinically significant improvements in melasma. By month 12, 80% of patients had 
      lesions completely cleared or nearly cleared. Once daily application of TC cream 
      applied intermittently over a long period is a safe, tolerable, and effective 
      treatment for moderate to severe melasma of the face.
FAU - Torok, Helen
AU  - Torok H
AD  - Trillium Creek Dermatology, Inc, Medina, OH 44526, USA. helenmtorok@aol.com
FAU - Taylor, Susan
AU  - Taylor S
FAU - Baumann, Leslie
AU  - Baumann L
FAU - Jones, Terry
AU  - Jones T
FAU - Wieder, Joshua
AU  - Wieder J
FAU - Lowe, Nicholas
AU  - Lowe N
FAU - Jarret, Michael
AU  - Jarret M
FAU - Rich, Pheobe
AU  - Rich P
FAU - Pariser, David
AU  - Pariser D
FAU - Tschen, Eduardo
AU  - Tschen E
FAU - Martin, Dale
AU  - Martin D
FAU - Menter, Alan
AU  - Menter A
FAU - Weiss, Jonathan
AU  - Weiss J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Dermatologic Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Hydroquinones)
RN  - 0 (Keratolytic Agents)
RN  - 0CD5FD6S2M (Fluocinolone Acetonide)
RN  - 5688UTC01R (Tretinoin)
RN  - XV74C1N1AE (hydroquinone)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Dermatologic Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Female
MH  - Fluocinolone Acetonide/administration & dosage/therapeutic use
MH  - Humans
MH  - Hydroquinones/administration & dosage/adverse effects/therapeutic use
MH  - Keratolytic Agents/administration & dosage/adverse effects/therapeutic use
MH  - Male
MH  - Melanosis/*drug therapy
MH  - Middle Aged
MH  - Tretinoin/administration & dosage/adverse effects/therapeutic use
EDAT- 2005/09/20 09:00
MHDA- 2005/10/27 09:00
CRDT- 2005/09/20 09:00
PHST- 2005/09/20 09:00 [pubmed]
PHST- 2005/10/27 09:00 [medline]
PHST- 2005/09/20 09:00 [entrez]
PST - ppublish
SO  - J Drugs Dermatol. 2005 Sep-Oct;4(5):592-7.