PMID- 16167888
OWN - NLM
STAT- MEDLINE
DCOM- 20071231
LR  - 20191109
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 25
IP  - 5
DP  - 2005
TI  - Molecular interactions between dendritic cells and Salmonella: escape from 
      adaptive immunity and implications on pathogenesis.
PG  - 389-403
AB  - Dendritic cells (DCs) constitute the link between innate and adaptive immunity by 
      directly recognizing pathogen-associated molecular patterns (PAMPs) on bacteria 
      and by processing and presenting bacterial antigens to T cells. Recognition of 
      PAMPs renders DCs as professional antigen-presenting cells with the ability to 
      prime naive T cells and to initiate the adaptive immune response against 
      pathogen-derived antigens. For this reason, any interference with DC function 
      might be advantageous for bacterial survival and dissemination. Identification of 
      the molecular interactions occurring between DCs and bacterial pathogens is 
      necessary to understand the mechanisms that virulent bacteria have evolved to 
      prevent recognition by the adaptive immune system. This could be helpful in the 
      identification of possible new targets that might lead to the design of effective 
      therapies aimed at preventing or treating serious infections by these pathogens. 
      In this article, we focus on Salmonella enterica serovar Typhimurium, the 
      causative agent of typhoid-like disease in the mouse, and how it is able to 
      escape from DC-mediated antigen presentation by avoiding lysosomal degradation. 
      This feature of virulent Salmonella requires the functional expression of the 
      Type Three Secretion System (TTSS) and effector proteins encoded within the 
      Salmonella pathogenicity island 2 (SPI-2). Recent studies have demonstrated that 
      impairment of DC function by the activity of SPI-2 gene products is crucial for 
      Salmonella pathogenesis.
FAU - Bueno, Susan M
AU  - Bueno SM
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Pontifica Universidad Catolica de Chile, Santiago.
FAU - Tobar, Jaime A
AU  - Tobar JA
FAU - Iruretagoyena, Mirentxu I
AU  - Iruretagoyena MI
FAU - Kalergis, Alexis M
AU  - Kalergis AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Dendritic Cells/*immunology/microbiology
MH  - *Immunity, Innate
MH  - Salmonella Infections/*immunology
MH  - Salmonella typhimurium/*immunology/*pathogenicity
MH  - Virulence Factors/physiology
RF  - 109
EDAT- 2005/09/20 09:00
MHDA- 2008/01/01 09:00
CRDT- 2005/09/20 09:00
PHST- 2005/09/20 09:00 [pubmed]
PHST- 2008/01/01 09:00 [medline]
PHST- 2005/09/20 09:00 [entrez]
AID - 7afe009f5855b332,4cf536f62d241bd8 [pii]
AID - 10.1615/critrevimmunol.v25.i5.40 [doi]
PST - ppublish
SO  - Crit Rev Immunol. 2005;25(5):389-403. doi: 10.1615/critrevimmunol.v25.i5.40.