PMID- 16167979
OWN - NLM
STAT- MEDLINE
DCOM- 20060227
LR  - 20061115
IS  - 0268-9146 (Print)
IS  - 0268-9146 (Linking)
VI  - 36
IP  - 5
DP  - 2005 Oct
TI  - Analysis of recessive lethality on swine chromosome 6 in a Gottingen miniature 
      resource family.
PG  - 376-80
AB  - Previously, we reported recessive gene(s) that terminate fetal development on 
      swine chromosome (SSC) 6 between SW855 and SW122. The affected alleles originated 
      from a Gottingen miniature pig used for construction of a Gottingen miniature pig 
      x Meishan resource population. However, it is not known when the gene(s) are 
      activated during fetal development, which is one of the important factors in 
      selecting candidate genes responsible for fetal death. In the present study, a 
      second swine population consisting of 159 progeny was produced by mating pigs 
      carrying the deleterious allele(s). This population allowed us to narrow the 
      genetic region harbouring the affected gene(s) and to demonstrate that the region 
      was confined between RYR1 and SW782 (5.7 cM on the National Institute of Animal 
      Industry (NIAI) map and 100 cR on the INRA/University of Minnesota porcine 
      radiation hybrid panel map). In order to determine when the affected gene(s) are 
      activated and in turn terminate fetal development, embryos produced in the second 
      population were collected at several development stages and genotyped for markers 
      in the region. Genes in the homozygous state affected embryo development between 
      9 and 11 days post-coitus.
FAU - Mikawa, S
AU  - Mikawa S
AD  - Genome Research Department, National Institute of Agrobiological Sciences, 
      Tsukuba, Ibaraki 305-0901, Japan.
FAU - Kishi, H
AU  - Kishi H
FAU - Ogawa, H
AU  - Ogawa H
FAU - Iga, K
AU  - Iga K
FAU - Uenishi, H
AU  - Uenishi H
FAU - Yasue, H
AU  - Yasue H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
SB  - IM
MH  - Animals
MH  - Breeding/methods
MH  - Chromosome Mapping
MH  - Chromosomes, Mammalian/*genetics
MH  - Crosses, Genetic
MH  - Embryonic Development/*genetics
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Genes, Recessive/*genetics
MH  - Genotype
MH  - Swine
MH  - Swine, Miniature/*genetics
EDAT- 2005/09/20 09:00
MHDA- 2006/02/28 09:00
CRDT- 2005/09/20 09:00
PHST- 2005/09/20 09:00 [pubmed]
PHST- 2006/02/28 09:00 [medline]
PHST- 2005/09/20 09:00 [entrez]
AID - AGE1322 [pii]
AID - 10.1111/j.1365-2052.2005.01322.x [doi]
PST - ppublish
SO  - Anim Genet. 2005 Oct;36(5):376-80. doi: 10.1111/j.1365-2052.2005.01322.x.