PMID- 16170394
OWN - NLM
STAT- MEDLINE
DCOM- 20060612
LR  - 20230105
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 149
IP  - 1
DP  - 2005 Jun
TI  - MCL-1 (myosin light chains-1) in differential diagnosis of dyspnea.
PG  - 89-91
LID - 10.5507/bp.2005.010 [doi]
AB  - Myosin light chains-1 (MLC-1) have been recently associated with the markers of 
      heart function (NYHA, LVEF, NT-proBNP). Verification of the relationship between 
      markers of heart function (New York Heart Association classification (NYHA), left 
      ventricle ejection fraction determination (LVEF), N terminal prohormone of 
      natriuretic peptide B type BNP (NT-proBNP) and concentrations of myosin light 
      chains-1 (MLC-1) was assessed. Patients examined for dyspnea without signs of 
      acute coronary syndrome. All patients underwent echocardiography (calculation of 
      left ventricle ejection fraction--LVEF) and in the serum of all subjects 
      NT-proBNP (ELEIA) and MLC-1 (ELISA) were determined. In the 38 patients (21 men, 
      17 women), mean age of 58 years (+/-12 years as 1 SD), a significant negative 
      correlation was found between NT-proBNP and LVEF (r = - 0.47; p = 0.02, 
      Spearman). The median levels of NT pro-BNP were closely associated with NYHA 
      classification (type II--584 ng/l, type III--2792 ng/l, type IV--6400 ng/l; p < 
      0.05). Individuals with clinical NYHA IV differed significantly in median MLC-1 
      concentrations from persons with clinical NYHA classification II and III (type 
      II--5.7 ng/l, type III--8.9 ng/l, type IV--17 ng/l; p < 0.05). A significant 
      negative correlation between MLC-1 and LVEF (-0.35; p < 0.03) and significant 
      positive correlations between MLC-1 and NT-proBNP (0.42; p < 0.012) were found. 
      In conclusion MLC-1 cannot be used as a diagnostic marker in differential 
      diagnosis of dyspnea.
FAU - Stejskal, David
AU  - Stejskal D
AD  - Department of Laboratory Medicine, Hospital Sternberk, Czech Republic. 
      david.stejskal@quick.cz
FAU - Lacnak, Borek
AU  - Lacnak B
FAU - Andelova, Katerina
AU  - Andelova K
FAU - Skvarilova, Marcela
AU  - Skvarilova M
FAU - Bartek, Josef
AU  - Bartek J
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
      Czechoslovakia
JID - 101140142
RN  - 0 (Biomarkers)
RN  - 0 (Myosin Light Chains)
RN  - 0 (Peptide Fragments)
RN  - 0 (myosin light chain I)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Biomarkers/blood
MH  - Diagnosis, Differential
MH  - Dyspnea/*etiology
MH  - Female
MH  - Heart Failure/complications/*diagnosis/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myosin Light Chains/*blood
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Stroke Volume
EDAT- 2005/09/20 09:00
MHDA- 2006/06/13 09:00
CRDT- 2005/09/20 09:00
PHST- 2005/09/20 09:00 [pubmed]
PHST- 2006/06/13 09:00 [medline]
PHST- 2005/09/20 09:00 [entrez]
AID - 10.5507/bp.2005.010 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun;149(1):89-91. doi: 
      10.5507/bp.2005.010.