PMID- 16170623
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20181113
IS  - 0967-3849 (Print)
IS  - 0967-3849 (Linking)
VI  - 13
IP  - 6
DP  - 2005
TI  - Meiotic instability of chicken ultra-long telomeres and mapping of a 2.8 megabase 
      array to the W-sex chromosome.
PG  - 581-91
AB  - The objective of this research was to study the meiotic stability of a subset of 
      chicken telomere arrays, which are the largest reported for any vertebrate 
      species. Inheritance of these ultra-long telomere arrays (200 kb to 3 mb) was 
      studied in a highly homozygous inbred line, UCD 003 (F >or= 99.9). Analysis of 
      array transmission in four families indicated unexpected heterogeneity and 
      non-Mendelian segregation including high-frequency-generation of novel arrays. 
      Additionally, the largest array detected (2.8 Mb) was female-specific and 
      correlated to the most intense telomeric DNA signal on the W-sex chromosome by 
      fluorescence in situ hybridization (FISH). These results are discussed in regard 
      to the potential functions of the ultra-long telomere arrays in the chicken 
      genome including generation of genetic variation through enhanced recombination, 
      protection against erosion by providing a buffer for gene-dense regions, and 
      sex-chromosome organization.
FAU - Rodrigue, K L
AU  - Rodrigue KL
AD  - Department of Animal Science, University of California, 2131D Meyer Hall, Davis, 
      CA 95616, USA.
FAU - May, B P
AU  - May BP
FAU - Famula, T R
AU  - Famula TR
FAU - Delany, M E
AU  - Delany ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050921
PL  - Netherlands
TA  - Chromosome Res
JT  - Chromosome research : an international journal on the molecular, supramolecular 
      and evolutionary aspects of chromosome biology
JID - 9313452
SB  - IM
MH  - Animals
MH  - Chickens/*genetics
MH  - Female
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Meiosis/*genetics
MH  - *Sex Chromosomes
MH  - *Telomere
EDAT- 2005/09/20 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/09/20 09:00
PHST- 2005/05/05 00:00 [received]
PHST- 2005/09/20 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/09/20 09:00 [entrez]
AID - 10.1007/s10577-005-0984-7 [doi]
PST - ppublish
SO  - Chromosome Res. 2005;13(6):581-91. doi: 10.1007/s10577-005-0984-7. Epub 2005 Sep 
      21.