PMID- 16172644
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20131121
IS  - 1477-9226 (Print)
IS  - 1477-9226 (Linking)
IP  - 19
DP  - 2005 Oct 7
TI  - Solution chemical properties and catecholase-like activity of the 
      copper(II)-Ac-His-His-Gly-His-OH system, a relevant functional model for copper 
      containing oxidases.
PG  - 3187-94
AB  - The solution chemical properties, superoxide dismutase and catecholase activity 
      of the copper(ii)-Ac-His-His-Gly-His-OH (hhgh) complexes were studied to identify 
      functional and structural models of copper-containing oxidases. The solution 
      speciation was determined in the pH range 3-11 by two independent methods 
      (potentiometry and pH-dependent EPR measurements). The results obtained by the 
      two methods agree very well with each other and show the formation of differently 
      protonated CuH(x)L complexes (where x= 2 ,1, 0, -1, -2, -3) in aqueous solution. 
      The spectroscopic (UV-Vis, CD, EPR) data indicate that the coordination of the 
      imidazole rings is a determinant factor in all these complexes. Amide coordinated 
      complexes are dominant only above pH 8. This offers excellent possibilities for 
      structural/functional modelling of copper(ii) containing metalloenzymes. Indeed, 
      the 3N(im) coordinated CuL species (pH = 6-7) has efficient superoxide 
      dismutase-like activity. The 3N(im),OH(-) coordinated CuH(-1)L possesses 
      outstanding activity to catalyze the oxidation of 3,5-di-tert-butylcatechol 
      (H(2)dtbc) by dioxygen in 86 wt% methanol-water, providing the first example that 
      copper(ii)-peptide complexes are able to mimic copper containing oxidases.
FAU - Jancso, A
AU  - Jancso A
AD  - Department of Chemistry, University of Turku, FIN-20014 Turku, Finland.
FAU - Paksi, Z
AU  - Paksi Z
FAU - Jakab, N
AU  - Jakab N
FAU - Gyurcsik, B
AU  - Gyurcsik B
FAU - Rockenbauer, A
AU  - Rockenbauer A
FAU - Gajda, T
AU  - Gajda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050819
PL  - England
TA  - Dalton Trans
JT  - Dalton transactions (Cambridge, England : 2003)
JID - 101176026
RN  - 0 (Catechols)
RN  - 0 (Oligopeptides)
RN  - 0 (Solutions)
RN  - 789U1901C5 (Copper)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.16.- (copper oxidase)
RN  - LF3AJ089DQ (catechol)
SB  - IM
MH  - Biomimetic Materials/*chemistry
MH  - Catechols/metabolism
MH  - Copper/*chemistry
MH  - Electrochemistry
MH  - Electron Spin Resonance Spectroscopy
MH  - Hydrogen-Ion Concentration
MH  - *Models, Molecular
MH  - Oligopeptides/*chemistry
MH  - Oxidoreductases/*chemistry
MH  - Solutions
EDAT- 2005/09/21 09:00
MHDA- 2007/04/06 09:00
CRDT- 2005/09/21 09:00
PHST- 2005/09/21 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2005/09/21 09:00 [entrez]
AID - 10.1039/b507655b [doi]
PST - ppublish
SO  - Dalton Trans. 2005 Oct 7;(19):3187-94. doi: 10.1039/b507655b. Epub 2005 Aug 19.