PMID- 16173529
OWN - NLM
STAT- MEDLINE
DCOM- 20051107
LR  - 20081121
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 33
IP  - 4
DP  - 2005
TI  - Association between tumor necrosis factor-alpha gene polymorphism and Sasang 
      constitution in cerebral infarction.
PG  - 547-57
AB  - During the last decade, a growing corpus of evidence has indicated an important 
      role of cytokines in the development of brain damage following cerebral ischemia. 
      Tumor necrosis factor-alpha (TNF-alpha), a potent immunomodulator and 
      pro-inflammatory cytokine, has been implicated in many pathological processes. In 
      this study, we examined whether promoter region polymorphism in the TNF-alpha 
      gene at position -308 affects the odds of cerebral infarction (CI) and whether 
      genetic risk is enhanced by Sasang constitutional classification. Two hundred and 
      twelve CI patients and 610 healthy controls were genotyped and determined 
      according to Sasang constitutional classification. A significant decrease was 
      found for the TNF-alpha A allele in CI patients compared with controls (p = 
      0.033, odds ratio, OR: 0.622). However, there was no significant association 
      between TNF-alpha polymorphism and Sasang constitution in CI patients. Our 
      finding suggests that TNF-alpha promoter region polymorphism is responsible for 
      susceptibility to CI in Koreans.
FAU - Um, Jae-Young
AU  - Um JY
AD  - Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 
      Seoul 130-701, Republic of Korea.
FAU - Lee, Jae-Heung
AU  - Lee JH
FAU - Joo, Jong-Cheon
AU  - Joo JC
FAU - Kim, Kyung-Yo
AU  - Kim KY
FAU - Lee, Eun-Hee
AU  - Lee EH
FAU - Shin, Taekyun
AU  - Shin T
FAU - Hong, Seung-Heon
AU  - Hong SH
FAU - Kim, Hyung-Min
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Constitution
MH  - Cerebral Infarction/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Korea
MH  - Male
MH  - *Medicine, East Asian Traditional
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2005/09/22 09:00
MHDA- 2005/11/08 09:00
CRDT- 2005/09/22 09:00
PHST- 2005/09/22 09:00 [pubmed]
PHST- 2005/11/08 09:00 [medline]
PHST- 2005/09/22 09:00 [entrez]
AID - S0192415X05003156 [pii]
AID - 10.1142/S0192415X05003156 [doi]
PST - ppublish
SO  - Am J Chin Med. 2005;33(4):547-57. doi: 10.1142/S0192415X05003156.