PMID- 16174491
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20191109
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 7
IP  - 5
DP  - 2005 Oct
TI  - Update of TNF-alpha antagonists and cardiovascular disease in rheumatoid 
      arthritis.
PG  - 395-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) antagonists were unexpectedly found to 
      have no beneficial effects in moderate-to-severe heart failure in two large 
      randomized clinical trials. In certain doses, the agents were found to be 
      harmful. These results have important implications for rheumatoid arthritis (RA). 
      Patients with the disease have an increased risk for developing cardiovascular 
      co-morbidity, including heart failure. Because of the beneficial effect of the 
      TNF-alpha antagonists in the management of RA, these agents have gained 
      widespread use. Rheumatologists and other physicians who provide care for RA are 
      thus likely to encounter candidates for anti-TNF-alpha therapy who have overt or 
      subclinical heart failure. Although data are currently not sufficient to support 
      evidence-based recommendations, it is possible to make reasonable suggestions to 
      guide clinical practice.
FAU - del Rincon, Inmaculada
AU  - del Rincon I
AD  - University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, 
      USA. delrincon@uthscsa.edu
FAU - Escalante, Agustin
AU  - Escalante A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor Decoy Receptors)
SB  - IM
MH  - Arthritis, Rheumatoid/complications/*drug therapy
MH  - Cardiovascular Diseases/etiology/*prevention & control
MH  - Humans
MH  - Neoplasm Proteins/*therapeutic use
MH  - Receptors, Cell Surface/*therapeutic use
MH  - Receptors, Tumor Necrosis Factor, Type II/*therapeutic use
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor Decoy Receptors
RF  - 43
EDAT- 2005/09/22 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/09/22 09:00
PHST- 2005/09/22 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/09/22 09:00 [entrez]
AID - 10.1007/s11926-005-0028-5 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2005 Oct;7(5):395-9. doi: 10.1007/s11926-005-0028-5.