PMID- 16176001
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20140625
VI  - 19
IP  - 12
DP  - 2005 Jun
TI  - [Expressions and clinical significance of urokinase-type activator (uPA) and uPA 
      receptor (uPAR) in laryngeal squamous cell carcinoma].
PG  - 529-31
AB  - OBJECTIVE: To study the expressions and clinical significance of urokinase-type 
      plasminogen activator (uPA) and uPA receptor (uPAR) in laryngeal squamous cell 
      carcinoma (LSCC). METHOD: The expressions of uPA and uPAR at protein level were 
      examined in 50 cases of LSCC and 10 cases of normal peripheral tissues around 
      cancer (as control) by strep avidin-biotin complex (SABC) immunohistochemical 
      technique. The relationship between the expressions of uPA and uPAR was evaluated 
      by the Spearman's rank correlation test. Mann-Whitney U-test was used to examine 
      association of these factors with conventional clinical pathological factors. 
      Pearson's chi-square test was used to analyze the relationship between uPA, uPAR 
      and cervical lymph node status. RESULT: The rates of the positive expression in 
      LSCC of uPA and uPAR were 66% and 62% respectively, and a positive relationship 
      between expression of uPA and uPAR (P < 0.05). There was significant correlation 
      between the level of uPA expression and TNM stage or cervical lymph node status, 
      either between the level of uPAR expression and TNM stage or cervical lymph node 
      status. Neither tumor size, T-category, nor grade was significantly related with 
      the level of uPA or uPAR expression. LSCC cases with concourse positive 
      expression of these proteins revealed significant higher tendency of cervical 
      lymph node metastasis than those with concourse negative expression (P < 0.01). 
      CONCLUSION: The expression of uPA and uPAR are increased in LSCC, and uPA, uPAR 
      may contribute significantly to LSCC invasion and metastasis.
FAU - Wang, Dali
AU  - Wang D
AD  - Department of Otorhinolaryngology, The Second Affiliated Hospital, China Medical 
      University, Shenyang, 110004, China. wsln2000@sina.com
FAU - Wang, Tie
AU  - Wang T
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (PLAUR protein, human)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Urokinase Plasminogen Activator)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neck
MH  - Receptors, Cell Surface/*biosynthesis
MH  - Receptors, Urokinase Plasminogen Activator
MH  - Urokinase-Type Plasminogen Activator/*biosynthesis
EDAT- 2005/09/24 09:00
MHDA- 2006/08/19 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jun;19(12):529-31.