PMID- 16176178
OWN - NLM
STAT- MEDLINE
DCOM- 20051206
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 43
IP  - 9
DP  - 2005
TI  - Diagnostic and analytical performance of a screening panel for allergy.
PG  - 963-6
AB  - Worldwide, allergic diseases are increasing in prevalence and incidence. Early 
      assessment of the immunoglobulin E (IgE) sensitisation status has a major impact 
      on clinical outcome and selection of therapeutic options. Recently, a number of 
      new IgE-detecting test systems have entered the market, including screening tests 
      allowing identification of a wide spectrum of sensitising allergens. We evaluated 
      the analytical and diagnostic performance of the newly developed Allergy Screen 
      test panel for atopy (Mediwiss Analytic, Moers, Germany). The evaluation was 
      performed for four major respiratory and four major nutritional allergens in 142 
      patients with clinical suspicion of respiratory and/or food allergies. For all 
      allergens, the test showed acceptable concordance to the skin-prick test and the 
      in vitro IgE CAP system (Pharmacia, Freiburg, Germany). The analytical 
      performance was acceptable, with CVs between 2 and 8% in the positive range and 
      good dilution linearity (R=0.9735). Imprecision in the low IgE concentration 
      range dramatically improved by lowering the cut-off value to 0.2 IU/mL IgE. In 
      conclusion, the Allergy Screen panel yields reliable results in the detection of 
      allergic sensitisation to common allergens.
FAU - Herzum, Ileana
AU  - Herzum I
AD  - Department of Clinical Chemistry and Molecular Diagnostics, Philipps University 
      of Marburg, 35033 Marburg, Germany. herzumi@med.uni-marburg.de
FAU - Blumer, Nicole
AU  - Blumer N
FAU - Kersten, Werner
AU  - Kersten W
FAU - Renz, Harald
AU  - Renz H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/adverse effects/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*diagnosis/immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Skin Tests
EDAT- 2005/09/24 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
AID - 10.1515/CCLM.2005.165 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2005;43(9):963-6. doi: 10.1515/CCLM.2005.165.