PMID- 16176341
OWN - NLM
STAT- MEDLINE
DCOM- 20060524
LR  - 20181201
IS  - 0767-3981 (Print)
IS  - 0767-3981 (Linking)
VI  - 19
IP  - 5
DP  - 2005 Oct
TI  - Topiramate prevents ecstasy consumption: a case report.
PG  - 601-2
AB  - The last decade has witnessed a development in the phenomenon 'ecstasy'. Several 
      substances, with more or less the same effects, are grouped together by the term 
      ecstasy, the best-known one being 3,4-methylenedioxymethamphetamine (MDMA). The 
      psychopathological consequences of MDMA in humans are relatively poorly 
      understood. In addition, the treatment approach is complicated by the lack of 
      documented studies. Topiramate is an antiepileptic drug that has a broad spectrum 
      of antiseizure effects, which appear to be the result of several neurostabilizing 
      pharmacological mechanisms including facilitation of GABAergic neurotransmission 
      and inhibition of glutametergic activity at AMPA/kainate receptors. As both 
      GABAergic and glutametergic neurons appear to be important modulators of the 
      brain reward system, it was postulated that topiramate would be an effective 
      treatment for reducing MDMA consumption through the attenuation of MDMA-induced 
      euphoria. The case of an ecstasy consumer, who started to discontinue ecstasy 
      under topiramate treatment is presented here. Antiepileptics/mood stabilizers 
      with glutamate inhibition activity like topiramate may present a promising new 
      approach for challenging the consequence of drug abuse.
FAU - Akhondzadeh, Shahin
AU  - Akhondzadeh S
AD  - Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran. s.akhond@neda.net
FAU - Hampa, Ali Daliri
AU  - Hampa AD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
RN  - 0 (Neuroprotective Agents)
RN  - 0H73WJJ391 (Topiramate)
RN  - 30237-26-4 (Fructose)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamine-Related Disorders/etiology/*prevention & control/psychology
MH  - Euphoria/drug effects
MH  - Fructose/*analogs & derivatives/therapeutic use
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*poisoning
MH  - Neuroprotective Agents/therapeutic use
MH  - Topiramate
EDAT- 2005/09/24 09:00
MHDA- 2006/05/25 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2006/05/25 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
AID - FCP355 [pii]
AID - 10.1111/j.1472-8206.2005.00355.x [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2005 Oct;19(5):601-2. doi: 
      10.1111/j.1472-8206.2005.00355.x.