PMID- 16177675
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20071115
IS  - 0026-4725 (Print)
IS  - 0026-4725 (Linking)
VI  - 53
IP  - 4
DP  - 2005 Aug
TI  - Relationship between B-type natriuretic peptide levels and ventilatory response 
      during cardiopulmonary exercise test in patients with chronic heart failure.
PG  - 313-20
AB  - AIM: Aim of the study was to evaluate if brain natriuretic peptide (BNP) levels, 
      a cardiac neurohormone well correlated with prognosis in chronic heart failure 
      (CHF), are associated with enhanced ventilatory response to exercise, in 
      ambulatory patients with intermediate peak oxygen uptake (PVO2). METHODS: Resting 
      BNP was measured in 129 consecutive stable CHF patients with mild to moderate 
      heart failure (90% New York Heart Association (NYHA) class II or III) and 
      intermediate (10-18 mL/kg/min) PVO2, assessed during cardiopulmonary exercise 
      test. Mean (SD) left ventricular ejection fraction (EF) and pulmonary systolic 
      pressure (PAP) were 41 +/- 3% and 47 +/- 14 mmHg, respectively. The enhanced 
      ventilatory response to exercise (EVR) was assessed as a slope of the relation 
      between minute ventilation and carbon dioxide production (VE/VCO2 slope) > 35. 
      RESULTS: Thirty-three over 129 patients (26%) had EVR. Mean BNP plasma level was 
      394 +/- 347 pg/mL. A significant correlation between BNP and EVR (r = 0.310; p < 
      0.01), was observed. In the logistic multivariate model, a BNP plasma level > 100 
      pg/mL had an independent predictive value for EVR (95% IC 1.68 to 10.5, Odds 
      Ratio 4.23, p = 0.02). We found a significant correlation between BNP and PAP (r 
      = 0.390; p < 0.001), and between PAP and EVR (r = 0.511; p < 0.01). CONCLUSIONS: 
      In CHF patients with intermediate PVO2, plasma BNP is clearly related to the 
      enhanced ventilatory response to exercise. In this subset, BNP levels could 
      represent an effective alternative tool for the clinical assessment in patients 
      with unreliable cardiopulmonary exercise test.
FAU - Scardovi, A B
AU  - Scardovi AB
AD  - Division of Cardiology, S. Spirito Hospital, Rome, Italy. ab.scardovi@libero.it
FAU - Coletta, C
AU  - Coletta C
FAU - Aspromonte, N
AU  - Aspromonte N
FAU - Perna, S
AU  - Perna S
FAU - Infusino, T
AU  - Infusino T
FAU - Carunchio, A
AU  - Carunchio A
FAU - D'Errigo, P
AU  - D'Errigo P
FAU - Seccareccia, F
AU  - Seccareccia F
FAU - De Maria, R
AU  - De Maria R
FAU - Greggi, M
AU  - Greggi M
FAU - Di Giacomo, T
AU  - Di Giacomo T
FAU - Ricci, R
AU  - Ricci R
FAU - Ceci, V
AU  - Ceci V
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Minerva Cardioangiol
JT  - Minerva cardioangiologica
JID - 0400725
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - *Exercise Test
MH  - Female
MH  - Heart Failure/*blood/*physiopathology
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Pulmonary Ventilation
MH  - Reproducibility of Results
EDAT- 2005/09/24 09:00
MHDA- 2006/03/22 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
PST - ppublish
SO  - Minerva Cardioangiol. 2005 Aug;53(4):313-20.