PMID- 16178446
OWN - NLM
STAT- MEDLINE
DCOM- 20060428
LR  - 20061115
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 27
IP  - 4
DP  - 2005 Aug
TI  - [Expression of monocyte chemoattractant protein-1 and lupus nephritis].
PG  - 491-5
AB  - OBJECTIVE: To explore the role of monocyte chemoattractant protein-1 (MCP-1) in 
      lupus nephritis (LN). METHODS: Sera MCP-1 levels were measured by enzyme linked 
      immunosorbent assay in 112 patients with systemic lupus erythematosus (SLE), 30 
      patients with rheumatoid arthritis, 11 non-SLE patients with renal impairment, 
      and 40 healthy volunteers. MCP-1 mRNA expression in peripheral blood mononuclear 
      cells (PBMCs) was also investigated with reverse trancription-polymerase chain 
      reaction semi-quantitative method. RESULTS: The expression of MCP-1 was 
      significantly higher in active LN groups than in all other groups (P < 0.001), 
      and there was a close correlation between MCP-1 expression and the overall SLE 
      disease activity index score (r=0.6245, P < 0.001) and the SLE disease activity 
      index renal score (r=0.6808, P < 0.001). Low expression of MCP-1 was observed in 
      diseased controls and healthy controls. The sera levels of MCP-1 were 
      significantly higher in patients with active diseases than in patients with 
      inactive SLE and controls, but no significant difference were found between the 
      active LN groups and non-renal involvement group (P >0.05). CONCLUSION: The 
      expression of PBMCs MCP-1 mRNA is upregulated in active SLE. Meanwhile, its 
      expression levels are correlated with the activity of LN.
FAU - Liu, Zhong-Juan
AU  - Liu ZJ
AD  - Department of Laboratory Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, 
      China. lzhj-0322@hotmail.com
FAU - Lin, Jia-You
AU  - Lin JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/metabolism
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*metabolism
MH  - Lupus Nephritis/*metabolism
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/biosynthesis/genetics
EDAT- 2005/09/24 09:00
MHDA- 2006/04/29 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2006/04/29 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Aug;27(4):491-5.