PMID- 16179502
OWN - NLM
STAT- MEDLINE
DCOM- 20060606
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1053
DP  - 2005 Aug
TI  - Neuropsychiatric alterations in MDMA users: preliminary findings.
PG  - 20-7
AB  - The use of marijuana is rampant among 3,4-methylenedioxymethamphetamine (MDMA) 
      users. The co-occurrence of abuse of these two drugs has made it difficult to 
      assess the specific residual effects of MDMA alone. As a first step toward 
      identifying the effects of long-term MDMA use, we studied 8 MDMA abusers, 8 
      marijuana/MDMA abusers, 15 marijuana abusers (matched in marijuana use without 
      MDMA use), and 17 control subjects. EEG, cerebral blood velocity by pulsed 
      transcranial Doppler (TCD), and psychological measures were collected. 
      Three-minute resting eyes-closed EEG recordings were obtained from 16 electrodes. 
      The EEG was converted to 6 frequency bands (delta, theta, alpha-1, alpha-2, 
      beta-1, and beta-2) using a fast Fourier transformation. Blood flow velocity was 
      determined using a temporal window for the right and left middle cerebral 
      arteries using TCD. Absolute log delta power in the EEG of MDMA abusers at 
      central electrode sites was significantly higher than that of the MDMA/marijuana, 
      marijuana abusers, and control subjects. There were also increases in alpha-2 EEG 
      power observed only in marijuana abusers. The blood flow measure, diastolic 
      velocity, was increased in MDMA abusers whether they used marijuana or not. 
      Because increases in delta power and perfusion deficits are associated with some 
      chronic disorders, our findings in these ecstasy abusers suggest that MDMA use 
      may be associated with a drug-induced neuropathological state. More research is 
      necessary to test these ideas.
FAU - Herning, Ronald I
AU  - Herning RI
AD  - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural 
      Research Program, 5500 Nathan Shock Drive, Baltimore, Maryland 21224. 
      rherning@intra.nida.nih.gov
FAU - Better, Warren
AU  - Better W
FAU - Tate, Kimberly
AU  - Tate K
FAU - Cadet, Jean L
AU  - Cadet JL
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Cerebrovascular Circulation/drug effects
MH  - Electroencephalography
MH  - Female
MH  - *Hallucinogens
MH  - Humans
MH  - Male
MH  - Marijuana Abuse/physiopathology/psychology
MH  - Mental Disorders/chemically induced/etiology/*psychology
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - Neuropsychological Tests
MH  - Psychological Tests
MH  - Substance-Related Disorders/*psychology
MH  - Ultrasonography, Doppler, Transcranial
EDAT- 2005/09/24 09:00
MHDA- 2006/06/07 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2006/06/07 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
AID - 1053/1/20 [pii]
AID - 10.1196/annals.1344.003 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2005 Aug;1053:20-7. doi: 10.1196/annals.1344.003.