PMID- 16179737
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20190608
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 230
IP  - 9
DP  - 2005 Oct
TI  - Amomum xanthiodes inhibits mast cell-mediated allergic reactions through the 
      inhibition of histamine release and inflammatory cytokine production.
PG  - 681-7
AB  - In this study, we investigated the effect of Amomum xanthiodes (Zingiberaceae) 
      extract (AXE) on the mast cell-mediated allergy model and studied the possible 
      mechanism of action. We found that AXE inhibited compound 48/80-induced systemic 
      reactions and plasma histamine release in mice. Additionally, AXE decreased 
      immunoglobulin E (IgE)-mediated local allergic reactions and passive cutaneous 
      anaphylaxis (PCA), and AXE dose-dependently attenuated the release of histamine 
      from rat peritoneal mast cells (RPMC) activated by compound 48/80 or IgE. The 
      amounts of AXE needed for inhibition of compound 48/80-induced plasma histamine 
      release and PCA were similar to disodium cromoglycate, the known anti-allergic 
      drug. We found that AXE increased the cAMP levels and decreased the compound 
      48/80-induced intracellular Ca2+. Furthermore, AXE attenuated the phorbol 
      12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor 
      necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast 
      cells. The inhibitory effect of AXE on the proinflammatory cytokines was nuclear 
      factor-kappaB (NF-kappaB)-dependent. In addition, AXE decreased PMA plus 
      A23187-induced degradation of IkappaBalphaand the nuclear translocation of 
      NF-kappaB. Our findings provide evidence that AXE inhibits mast cell-derived 
      immediate-type allergic reactions, and that cAMP, intracellular Ca2+, 
      proinflammatory cytokines, and NF-kappaB are involved in these effects.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Department of Pharmacology, School of Medicine, Kyungpook National University, 
      Daegu, South Korea.
FAU - Shin, Tae-Yong
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Amomum/*chemistry
MH  - Animals
MH  - Cells, Cultured
MH  - Cyclic AMP/metabolism
MH  - Histamine Release/*drug effects
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Inflammation Mediators/*metabolism
MH  - Interleukin-6/*biosynthesis
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - NF-kappa B/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2005/09/24 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/09/24 09:00
PHST- 2005/09/24 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/24 09:00 [entrez]
AID - 230/9/681 [pii]
AID - 10.1177/153537020523000911 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2005 Oct;230(9):681-7. doi: 10.1177/153537020523000911.