PMID- 16180718
OWN - NLM
STAT- MEDLINE
DCOM- 20051014
LR  - 20190922
IS  - 0022-0299 (Print)
IS  - 0022-0299 (Linking)
VI  - 72 Spec No
DP  - 2005
TI  - Genetically modified mouse models to study the role of metastasis-promoting 
      S100A4(mts1) protein in metastatic mammary cancer.
PG  - 27-33
AB  - Transgenic and knockout mouse models are extensively used to study the mechanisms 
      of tumour formation. The availability of mouse models to study metastatic spread 
      of tumours is although quite limited. S100A4(mts1), that belongs to the S100 
      family of Ca-binding proteins, has been shown to function as a 
      metastasis-promoting protein. We generated strains of mice with modified 
      expression of S100A4 in order to understand the mechanism by which S100A4 protein 
      stimulates metastatic spread of the tumour cells. Transgenic mice over-expressing 
      the S100A4 gene in the mammary gland were crossed with GRS/A mice, characterized 
      by a high incidence of spontaneous non-metastatic mammary tumours. The resulting 
      hybrid mice developed metastatic tumours. Transgenic mice with ubiquitous 
      expression of S100A4 developed vascular tumours, hemangiomas and contained 
      enhanced levels of the S100A4 protein in the blood. Based on these observations 
      we demonstrated that extracellular S100A4 functions as an angiogenic factor. 
      Study of tumour development in the S100A4-deficient mouse model demonstrated key 
      role of extracellular S100A4 in stimulation of tumour development and metastasis 
      formation.
FAU - Ambartsumian, Noona
AU  - Ambartsumian N
AD  - Department of Molecular Cancer Biology, Institute for Cancer Biology, Danish 
      Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark. na@cancer.dk
FAU - Grigorian, Mariam
AU  - Grigorian M
FAU - Lukanidin, Eugene
AU  - Lukanidin E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Dairy Res
JT  - The Journal of dairy research
JID - 2985125R
RN  - 0 (S100 Calcium-Binding Protein A4)
RN  - 0 (S100 Proteins)
RN  - 0 (S100a4 protein, mouse)
SB  - IM
MH  - Animals
MH  - Mammary Neoplasms, Animal/*pathology
MH  - Mice
MH  - *Mice, Knockout
MH  - *Mice, Transgenic
MH  - *Neoplasm Metastasis
MH  - S100 Calcium-Binding Protein A4
MH  - S100 Proteins/deficiency/genetics/*physiology
RF  - 43
EDAT- 2005/09/27 09:00
MHDA- 2005/10/15 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2005/10/15 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - 10.1017/s0022029905001093 [doi]
PST - ppublish
SO  - J Dairy Res. 2005;72 Spec No:27-33. doi: 10.1017/s0022029905001093.