PMID- 16180961
OWN - NLM
STAT- MEDLINE
DCOM- 20051129
LR  - 20061115
IS  - 1088-0224 (Print)
IS  - 1088-0224 (Linking)
VI  - 11
IP  - 8 Suppl
DP  - 2005 Sep
TI  - Atypical antipsychotics and the burden of disease.
PG  - S235-41
AB  - The atypical antipsychotics are defined by improved tolerability in comparison 
      with conventional antipsychotics. Specifically, the atypicals are substantially 
      less likely to cause troubling extrapyramidal symptoms and prolactin elevation. 
      This reduction in adverse effects (AEs) is attributed to their short duration of 
      occupancy at dopamine-2 receptors in the central nervous system and a high degree 
      of activity at serotonin receptors of various subtypes. The main AEs associated 
      with the atypicals are weight gain and metabolic effects, including disturbances 
      in glucose metabolism and a risk of induced diabetes. However, the atypicals are 
      not interchangeable: the risk of incurring these effects is high with clozapine 
      and olanzapine, moderate with risperidone and quetiapine (but perhaps increasing 
      at higher doses), and minimal with ziprasidone and aripiprazole. The atypicals 
      have proved useful as monotherapy in treating schizophrenia and in combination 
      with other psychoactive agents in treating bipolar disorder. Because of their 
      improved tolerability, the atypicals offer the prospect of improved compliance 
      and reduced risk of relapse, thus decreasing costs by the need for less 
      hospitalization.
FAU - Simpson, George M
AU  - Simpson GM
AD  - Department of Psychiatry and the Behavioral Sciences, LAC + USC Medical Center, 
      Los Angeles, CA 90033, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Manag Care
JT  - The American journal of managed care
JID - 9613960
RN  - 0 (Antipsychotic Agents)
MH  - Antipsychotic Agents/*adverse effects/classification/therapeutic use
MH  - *Cost of Illness
MH  - Drug Tolerance
MH  - Humans
MH  - United States
EDAT- 2005/09/27 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - 2953 [pii]
PST - ppublish
SO  - Am J Manag Care. 2005 Sep;11(8 Suppl):S235-41.