PMID- 16181111
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20191109
IS  - 1567-2026 (Print)
IS  - 1567-2026 (Linking)
VI  - 2
IP  - 2
DP  - 2005 Apr
TI  - Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by 
      methionine intake.
PG  - 175-8
AB  - This study was designed to determine the protective effect of melatonin treatment 
      against oxidative damage in rat brain induced by hyperhomocysteinemia (Hhcy). 
      Oral administration of methionine and its degradation product, homocysteine 
      (hcy), causes mild to moderate Hhcy. The major end-point of oxidative damage 
      measured in this report was lipid peroxidation (LPO). The levels of 
      malondialdehyde (MDA) were assayed as index of lipid peroxidation. The increase 
      in lipid peroxidation was inhibited by melatonin. Rats were divided into seven 
      groups: one was used as control and each remaining group was supplemented with 
      methionine dissolved and added to the drinking water daily for 4 weeks (0.5, 1, 
      1.5, 2, 3 g /kg BW). Additional groups of rats were given both melatonin (30 
      mg/kg BW) and methionine in drinking water daily. At the conclusion of the study, 
      MDA levels were significantly increased in the brains of methionine-treated rats 
      compared with control rats, whereas melatonin prevented the increases in MDA 
      levels. Plasma hcy levels in animals treated with melatonin were significantly 
      lower than those of controls. Melatonin lowered plasma hcy levels and could 
      potentially be beneficial in prevention of neurodegeneration caused by mild 
      hyperhomocysteinemia.
FAU - Bouzouf, Mounir
AU  - Bouzouf M
AD  - Department of Medical Biochemistry and Molecular Biology, University of Seville 
      School of Medicine and Virgen Macarena Hospital, Sevilla, Spain.
FAU - Martinez-Cruz, Francisco
AU  - Martinez-Cruz F
FAU - Molinero, Patrocinio
AU  - Molinero P
FAU - Guerrero, Juan M
AU  - Guerrero JM
FAU - Osuna, Carmen
AU  - Osuna C
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Antioxidants)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - AE28F7PNPL (Methionine)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Brain/*metabolism
MH  - Homocysteine/blood/metabolism
MH  - Hyperhomocysteinemia/*prevention & control
MH  - Lipid Peroxidation/*drug effects
MH  - Male
MH  - Malondialdehyde/antagonists & inhibitors/metabolism
MH  - Melatonin/*pharmacology
MH  - Methionine/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
EDAT- 2005/09/27 09:00
MHDA- 2005/10/28 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - 10.2174/1567202053586839 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2005 Apr;2(2):175-8. doi: 10.2174/1567202053586839.