PMID- 16181343
OWN - NLM
STAT- MEDLINE
DCOM- 20051114
LR  - 20050926
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 207
DP  - 2005 Oct
TI  - Right place, right time, right peptide: DO keeps DM focused.
PG  - 279-92
AB  - Peptide loading of major histocompatibility class II molecules is catalyzed in 
      late endosomal and lysosomal compartments of cells by the catalytic action of 
      human leukocyte antigen (HLA)-DM (H-2M in mice). In B cells, dendritic cells and 
      thymic epithelial cells, the peptide loading of class II molecules is modified by 
      the expression of the non-classical class II molecule, HLA-DO (H-2O in mice). 
      Collectively, studies to date support that DO/H-2O expression inhibits the 
      presentation of antigens acquired by cells via fluid phase endocytosis. However, 
      in B cells, the expression of H-2O promotes the presentation of antigens 
      internalized by the B-cell receptor. In this review, we summarize the literature 
      pertaining to DO assembly, transport, and function, with an emphasis on the 
      function of DO/H-2O.
FAU - Denzin, Lisa K
AU  - Denzin LK
AD  - Sloan-Kettering Institute, Immunology Program, Memorial Sloan-Kettering Cancer 
      Center, NY 10021, USA. denzinl@mskcc.org
FAU - Fallas, Jennifer L
AU  - Fallas JL
FAU - Prendes, Maria
AU  - Prendes M
FAU - Yi, Woelsung
AU  - Yi W
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (HLA-D Antigens)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - B-Lymphocytes/cytology/immunology
MH  - Cell Differentiation/immunology
MH  - HLA-D Antigens/*immunology/metabolism
MH  - Humans
MH  - Lymphocyte Activation/immunology
MH  - Peptides/*immunology/metabolism
RF  - 120
EDAT- 2005/09/27 09:00
MHDA- 2005/11/15 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2005/11/15 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - IMR302 [pii]
AID - 10.1111/j.0105-2896.2005.00302.x [doi]
PST - ppublish
SO  - Immunol Rev. 2005 Oct;207:279-92. doi: 10.1111/j.0105-2896.2005.00302.x.