PMID- 16181471
OWN - NLM
STAT- MEDLINE
DCOM- 20060112
LR  - 20151119
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 153
IP  - 4
DP  - 2005 Oct
TI  - Richter syndrome first manifesting as cutaneous B-cell lymphoma clonally distinct 
      from primary B-cell chronic lymphocytic leukaemia.
PG  - 833-7
AB  - Richter syndrome (RS) is a transformation to high-grade non-Hodgkin lymphoma in 
      patients with chronic lymphocytic leukaemia (CLL). RS may develop in lymph nodes 
      or rarely extranodally. Skin localization of RS has been described in only a few 
      cases. We present a 77-year-old woman who developed isolated diffuse large B-cell 
      lymphoma (LBCL) in the skin of the nose without any other symptoms of RS. The 
      LBCL in the skin was clonally distinct from the original bone marrow CLL cells. 
      Moreover, LBCL cells were positive for LMP-1 segment of Epstein-Barr virus and 
      overexpressed p53 protein. The patient was successfully treated with CHOP 
      (cyclophosphamide, doxorubicin, vincristine and prednisone) and adjuvant local 
      radiotherapy.
FAU - Robak, E
AU  - Robak E
AD  - Department of Dermatology, Medical University of Lodz, Lodz, Poland. 
      robaktad@csk.umed.lodz.pl
FAU - Gora-Tybor, J
AU  - Gora-Tybor J
FAU - Kordek, R
AU  - Kordek R
FAU - Wawrzyniak, E
AU  - Wawrzyniak E
FAU - Bartkowiak, J
AU  - Bartkowiak J
FAU - Bednarek, A
AU  - Bednarek A
FAU - Constantinou, M
AU  - Constantinou M
FAU - Kaluzewski, B
AU  - Kaluzewski B
FAU - Robak, T
AU  - Robak T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 5J49Q6B70F (Vincristine)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - VB0R961HZT (Prednisone)
RN  - CHOP protocol
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Cyclophosphamide/therapeutic use
MH  - Doxorubicin/therapeutic use
MH  - Female
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
MH  - Lymphoma, B-Cell/drug therapy/*pathology
MH  - Neoplasms, Second Primary/drug therapy/pathology
MH  - Neoplastic Stem Cells/*pathology
MH  - Nose Neoplasms/drug therapy/*pathology
MH  - Prednisone/therapeutic use
MH  - Skin Neoplasms/drug therapy/*pathology
MH  - Syndrome
MH  - Vincristine/therapeutic use
EDAT- 2005/09/27 09:00
MHDA- 2006/01/13 09:00
CRDT- 2005/09/27 09:00
PHST- 2005/09/27 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/09/27 09:00 [entrez]
AID - BJD6805 [pii]
AID - 10.1111/j.1365-2133.2005.06805.x [doi]
PST - ppublish
SO  - Br J Dermatol. 2005 Oct;153(4):833-7. doi: 10.1111/j.1365-2133.2005.06805.x.